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    Wdr54 WD repeat domain 54 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500226, updated on 27-Dec-2024

    Summary

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    Symbol
    Wdr54provided by RGD
    Full Name
    WD repeat domain 54provided by RGD
    Primary source
    RGD:1561494
    See related
    EnsemblRapid:ENSRNOG00000009324 AllianceGenome:RGD:1561494
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561494
    Summary
    Predicted to enable protein homodimerization activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Located in cytoplasm and plasma membrane. Orthologous to human WDR54 (WD repeat domain 54). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 76.4), Testes (RPKM 50.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr54 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117212677..117236456, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115654968..115677979, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (114847722..114871989, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350719 Neighboring gene INO80 complex subunit B Neighboring gene rhotekin Neighboring gene similar to human chromosome 2 open reading frame 81 Neighboring gene dynactin subunit 1 Neighboring gene solute carrier family 4 member 5 Neighboring gene uncharacterized LOC134486596 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO. Lai X, et al. Theriogenology, 2024 Jan 15. PMID 37951137
    2. Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling. Maeda A, et al. Biochim Biophys Acta Mol Cell Res, 2019 Feb. PMID 30458214
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO.
      Title: Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 54

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109245.1 → NP_001102715.1  WD repeat-containing protein 54

      See identical proteins and their annotated locations for NP_001102715.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A6IAL0, D3ZX63
      Related
      ENSRNOP00000013128.3, ENSRNOT00000013128.7
      Conserved Domains (2) summary
      COG2319
      Location:131 → 324
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:72 → 119
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117212677..117236456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236781.5 → XP_006236843.1  WD repeat-containing protein 54 isoform X1

      See identical proteins and their annotated locations for XP_006236843.1

      UniProtKB/TrEMBL
      A6IAL0, D3ZX63
      Conserved Domains (2) summary
      COG2319
      Location:131 → 324
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:72 → 119
      7WD40; WD40 repeat [structural motif]

    2. XM_006236780.5 → XP_006236842.1  WD repeat-containing protein 54 isoform X1

      See identical proteins and their annotated locations for XP_006236842.1

      UniProtKB/TrEMBL
      A6IAL0, D3ZX63
      Conserved Domains (2) summary
      COG2319
      Location:131 → 324
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:72 → 119
      7WD40; WD40 repeat [structural motif]

    3. XM_039108151.2 → XP_038964079.1  WD repeat-containing protein 54 isoform X1

      UniProtKB/TrEMBL
      A6IAL0, D3ZX63
      Conserved Domains (2) summary
      COG2319
      Location:131 → 324
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:72 → 119
      7WD40; WD40 repeat [structural motif]

    4. XM_006236778.4 → XP_006236840.1  WD repeat-containing protein 54 isoform X1

      See identical proteins and their annotated locations for XP_006236840.1

      UniProtKB/TrEMBL
      A6IAL0, D3ZX63
      Conserved Domains (2) summary
      COG2319
      Location:131 → 324
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:72 → 119
      7WD40; WD40 repeat [structural motif]

    5. XM_063286524.1 → XP_063142594.1  WD repeat-containing protein 54 isoform X1

      UniProtKB/TrEMBL
      A6IAL0, D3ZX63
    Nucleotide Protein Strain
    Heading Accession and Version

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