Ctdspl CTD small phosphatase like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctdsplprovided by RGD
Official Full Name: CTD small phosphatase likeprovided by RGD
Primary source: RGD:1304841
See related: EnsemblRapid:ENSRNOG00000046257 AllianceGenome:RGD:1304841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Orthologous to human CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 64.5), Kidney (RPKM 60.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (127520478..127644999)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (118642729..118767238)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (127065292..127726248)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE105202 (e-PCR)
- UniSTS:245782

D8Got194 (e-PCR)
- UniSTS:112670

d8rat118 (e-PCR)
- UniSTS:122401

BE097955 (e-PCR)
- UniSTS:244785

RH144577 (e-PCR)
- UniSTS:233822

RH144327 (e-PCR)
- UniSTS:233572

RH142543 (e-PCR)
- UniSTS:231790

BE114426 (e-PCR)
- UniSTS:247521

AW533609 (e-PCR)
- UniSTS:245993

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CTD small phosphatase-like protein

Names: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

NP_001100335.1

EC 3.1.3.16

NP_001382669.1

EC 3.1.3.16

XP_038937226.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106865.1 → NP_001100335.1 CTD small phosphatase-like protein isoform 2

Status: VALIDATED

Source sequence(s)

CH473954

UniProtKB/TrEMBL

A6I3U6

Conserved Domains (1) summary

cl21460
Location:1 → 108

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001395740.1 → NP_001382669.1 CTD small phosphatase-like protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

M0R4W4

Related

ENSRNOP00000064414.2, ENSRNOT00000075793.4

Conserved Domains (1) summary

TIGR02251
Location:106 → 265

HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

127520478..127644999

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081298.2 → XP_038937226.1 CTD small phosphatase-like protein isoform X1

UniProtKB/TrEMBL

A0A8I6GE87

Related

ENSRNOP00000111038.1, ENSRNOT00000144382.1

Conserved Domains (1) summary

TIGR02251
Location:95 → 254

HIF-SF_euk; Dullard-like phosphatase domain