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    beag beag [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    beagprovided by FlyBase
    Official Full Name
    beagprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037660
    Locus tag
    Dmel_CG18005
    See related
    AllianceGenome:FB:FBgn0037660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18005; Dmel\CG18005
    Summary
    Involved in neuromuscular junction development; neuromuscular synaptic transmission; and terminal button organization. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in neurons. Orthologous to human IK (IK cytokine). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See beag in Genome Data Viewer
    Location:
    85C4-85C4; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9063132..9065078, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4888854..4890800, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NAD-dependent methylenetetrahydrofolate dehydrogenase Neighboring gene Mst85C Neighboring gene Relish Neighboring gene Lysine demethylase 2 Neighboring gene Adenosine deaminase Neighboring gene pumilio Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster. Zheng Y, et al. Mech Dev, 2014 Aug. PMID 25016215, Free PMC Article
    2. The Lysine Demethylase dKDM2 Is Non-essential for Viability, but Regulates Circadian Rhythms in Drosophila. Zheng Y, et al. Front Genet, 2018. PMID 30233643, Free PMC Article
    3. Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag. Beck ES, et al. J Neurosci, 2012 May 16. PMID 22593074, Free PMC Article
    4. ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila. Wu J, et al. Cell Microbiol, 2007 Apr. PMID 17166233
    5. Alternative splicing in Drosophila neuronal development. Mohr C, et al. J Neurogenet, 2014 Sep-Dec. PMID 24957133

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    beag
    Names
    CG18005-PA
    beag-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9063132..9065078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141608.3 → NP_649865.1  beag [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHH8
      Related
      FBpp0081475
      Conserved Domains (2) summary
      pfam07807
      Location:434 → 539
      RED_C; RED-like protein C-terminal region
      pfam07808
      Location:87 → 315
      RED_N; RED-like protein N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHH8 Q9VHH8

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