Prosalpha1 Proteasome alpha1 subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prosalpha1provided by FlyBase
Official Full Name: Proteasome alpha1 subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0263121
Locus tag: Dmel_CG18495
See related: AllianceGenome:FB:FBgn0263121
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 18495; alpha-1; Alpha-1; alpha1; CG18495; Dmel\CG18495; l(2)SH2 2342; l(2)SH2342; Pros alpha1; prosalpha1; prosalpha6; Prosalpha6; PSA6_DROME
Summary: Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult heart and organism. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43E18-43E18; 2-57 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7827303..7828678, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3714808..3716183, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome alpha1 subunit

Names: 20S proteasome subunit alpha1; 20s proteasome; CG18495-PA; CG18495-PB; Prosalpha1-PA; Prosalpha1-PB; alpha-subunit of 20S proteasome; alpha1; lethal (2) SH2342; proteasome alpha6; proteasome alpha6 subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7827303..7828678 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165565.3 → NP_724614.1 proteasome alpha1 subunit, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724614.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0E9G1, Q9V324, Q9XZJ4

UniProtKB/TrEMBL

E1JGZ9

Related

FBpp0087970

Conserved Domains (2) summary

COG0638
Location:7 → 243

PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]

cd03754
Location:8 → 218

proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
NM_080098.4 → NP_524837.2 proteasome alpha1 subunit, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524837.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0E9G1, Q9V324, Q9XZJ4

UniProtKB/TrEMBL

E1JGZ9

Related

FBpp0087969

Conserved Domains (2) summary

COG0638
Location:7 → 243

PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]

cd03754
Location:8 → 218

proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...