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    SmE Small ribonucleoprotein particle protein SmE [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SmEprovided by FlyBase
    Official Full Name
    Small ribonucleoprotein particle protein SmEprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261790
    Locus tag
    Dmel_CG18591
    See related
    AllianceGenome:FB:FBgn0261790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM19936; CG18591; dE; Dmel\CG18591; E; E-Sm; snRNPE
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in nucleus. Part of small nuclear ribonucleoprotein complex. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; hypotrichosis 1; hypotrichosis 11; and lupus nephritis. Orthologous to human SNRPE (small nuclear ribonucleoprotein polypeptide E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SmE in Genome Data Viewer
    Location:
    28D2-28D2; 2-29 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7884930..7885450, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7884930..7885450, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-3 Neighboring gene spatzle 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serpin 28Da

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polypeptide components of Drosophila small nuclear ribonucleoprotein particles. Paterson T, et al. Nucleic Acids Res, 1991 Nov 11. PMID 1834995, Free PMC Article
    2. Precursor RNA processing 3 is required for male fertility, and germline stem cell self-renewal and differentiation via regulating spliceosome function in Drosophila testes. Chen X, et al. Sci Rep, 2019 Jul 10. PMID 31292463, Free PMC Article
    3. Small ribonucleoprotein particle protein SmD3 governs the homeostasis of germline stem cells and the crosstalk between the spliceosome and ribosome signals in Drosophila. Yu J, et al. FASEB J, 2019 Jul. PMID 30921522
    4. Srlp is crucial for the self-renewal and differentiation of germline stem cells via RpL6 signals in Drosophila testes. Yu J, et al. Cell Death Dis, 2019 Apr 1. PMID 30931935, Free PMC Article
    5. Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster. Matera AG, et al. G3 (Bethesda), 2019 Feb 7. PMID 30563832, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small nuclear ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribonucleoprotein particle protein SmE
    Names
    CG18591-PA
    SmE-PA
    snRNPE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7884930..7885450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135318.2 → NP_609162.1  small ribonucleoprotein particle protein SmE [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLV5
      UniProtKB/TrEMBL
      A0A1B2AJY7
      Related
      FBpp0079182
      Conserved Domains (1) summary
      cd01718
      Location:10 → 88
      Sm_E; Sm protein E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLV5.1 Q9VLV5

    Gene LinkOut

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