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    LTK leukocyte receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4058, updated on 4-Jan-2025

    Summary

    Official Symbol
    LTKprovided by HGNC
    Official Full Name
    leukocyte receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6721
    See related
    Ensembl:ENSG00000062524 MIM:151520; AllianceGenome:HGNC:6721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TYK1
    Summary
    The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
    Expression
    Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LTK in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41503637..41513827, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39309799..39319984, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41795835..41806025, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene uncharacterized LOC105370790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9282 Neighboring gene Sharpr-MPRA regulatory region 6351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41784974-41785474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41785475-41785975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6361 Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41804857-41805604 Neighboring gene RNA polymerase II associated protein 1 Neighboring gene MPRA-validated peak2307 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41835695-41836276 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41844728-41844829 Neighboring gene elongin C pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase collagen receptor activity  
    enables receptor signaling protein tyrosine kinase activator activity PubMed 
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell population proliferation PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway PubMed 
    involved_in cellular response to retinoic acid PubMed 
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in multicellular organism development  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in peptidyl-tyrosine autophosphorylation PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of cardiac muscle cell apoptotic process PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of cell population proliferation  
    involved_in regulation of neuron differentiation  
    involved_in signal transduction PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in membrane PubMed 
    is_active_in plasma membrane  
    is_active_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of receptor complex  

    General protein information

    Preferred Names
    leukocyte tyrosine kinase receptor
    Names
    protein tyrosine kinase 1
    NP_001129157.1
    NP_002335.2
    NP_996844.1
    XP_011519859.1
    XP_024305687.2
    XP_047288455.1
    XP_047288456.1
    XP_047288457.1
    XP_047288458.1
    XP_047288459.1
    XP_047288461.1
    XP_047288462.1
    XP_054233880.1
    XP_054233881.1
    XP_054233882.1
    XP_054233883.1
    XP_054233884.1
    XP_054233885.1
    XP_054233886.1
    XP_054233887.1
    XP_054233888.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135685.2 → NP_001129157.1  leukocyte tyrosine kinase receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal coding exons and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (3) is missing two internal segments and has a short segment in an alternate reading frame but with the same N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC016134, AC087721, AK296892, CA394397
      Consensus CDS
      CCDS45237.1
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000392196.2, ENST00000453182.2
      Conserved Domains (2) summary
      pfam07714
      Location:415 → 647
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:414 → 649
      PKc_like; Protein Kinases, catalytic domain
    2. NM_002344.6 → NP_002335.2  leukocyte tyrosine kinase receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_002335.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC087721, AK296892, CA394397, D16105
      Consensus CDS
      CCDS10077.1
      UniProtKB/Swiss-Prot
      A6NNJ8, B4DL89, E9PFX4, P29376
      Related
      ENSP00000263800.6, ENST00000263800.11
      Conserved Domains (2) summary
      cd05036
      Location:503 → 779
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:510 → 777
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_206961.4 → NP_996844.1  leukocyte tyrosine kinase receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_996844.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is lacking one of the internal coding exons compared to variant 1. This results in an isoform (2) that is missing a 61 aa segment compared to isoform 1.
      Source sequence(s)
      AC016134, AC087721, CA394397, X60702
      Consensus CDS
      CCDS10078.1
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000347293.5, ENST00000355166.9
      Conserved Domains (2) summary
      cd05036
      Location:442 → 718
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:449 → 716
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      41503637..41513827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432499.1 → XP_047288455.1  leukocyte tyrosine kinase receptor isoform X2

    2. XM_047432501.1 → XP_047288457.1  leukocyte tyrosine kinase receptor isoform X4

    3. XM_047432502.1 → XP_047288458.1  leukocyte tyrosine kinase receptor isoform X5

    4. XM_047432500.1 → XP_047288456.1  leukocyte tyrosine kinase receptor isoform X3

    5. XM_011521557.3 → XP_011519859.1  leukocyte tyrosine kinase receptor isoform X1

      Conserved Domains (2) summary
      cd05036
      Location:463 → 739
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:470 → 737
      Pkinase_Tyr; Protein tyrosine kinase
    6. XM_047432505.1 → XP_047288461.1  leukocyte tyrosine kinase receptor isoform X7

      UniProtKB/TrEMBL
      H3BVG6
    7. XM_024449919.2 → XP_024305687.2  leukocyte tyrosine kinase receptor isoform X6

      UniProtKB/TrEMBL
      H3BVG6
    8. XM_047432503.1 → XP_047288459.1  leukocyte tyrosine kinase receptor isoform X6

      UniProtKB/TrEMBL
      H3BVG6
      Related
      ENSP00000458111.1, ENST00000561619.5
    9. XM_047432506.1 → XP_047288462.1  leukocyte tyrosine kinase receptor isoform X8

    RNA

    1. XR_007064446.1 RNA Sequence

    2. XR_007064447.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      39309799..39319984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377906.1 → XP_054233881.1  leukocyte tyrosine kinase receptor isoform X2

    2. XM_054377908.1 → XP_054233883.1  leukocyte tyrosine kinase receptor isoform X4

    3. XM_054377909.1 → XP_054233884.1  leukocyte tyrosine kinase receptor isoform X5

    4. XM_054377907.1 → XP_054233882.1  leukocyte tyrosine kinase receptor isoform X3

    5. XM_054377905.1 → XP_054233880.1  leukocyte tyrosine kinase receptor isoform X1

    6. XM_054377912.1 → XP_054233887.1  leukocyte tyrosine kinase receptor isoform X7

      UniProtKB/TrEMBL
      H3BVG6
    7. XM_054377911.1 → XP_054233886.1  leukocyte tyrosine kinase receptor isoform X6

      UniProtKB/TrEMBL
      H3BVG6
    8. XM_054377910.1 → XP_054233885.1  leukocyte tyrosine kinase receptor isoform X6

      UniProtKB/TrEMBL
      H3BVG6
    9. XM_054377913.1 → XP_054233888.1  leukocyte tyrosine kinase receptor isoform X8

    RNA

    1. XR_008488947.1 RNA Sequence

    2. XR_008488948.1 RNA Sequence

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