MIC26 Mic26p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MIC26
Official Full Name: Mic26p
Primary source: SGD:S000003467
Locus tag: YGR235C
See related: AllianceGenome:SGD:S000003467; FungiDB:YGR235C; VEuPathDB:YGR235C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MCS29; MIO27; MOS2
Summary: Involved in cristae formation. Acts upstream of or within negative regulation of protein oligomerization. Located in mitochondrial crista junction. Part of MICOS complex. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features.
Title: Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features.
Results find that Mic26 and Mic27 regulate Mic10 oligomerization in an antagonistic manner.
Title: Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cristae formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cristae formation	IEA Inferred from Electronic Annotation more info
involved_in cristae formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein oligomerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MICOS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MICOS complex	IDA Inferred from Direct Assay more info	PubMed
part_of MICOS complex	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial crista junction	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial crista junction	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_011751.1

Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; negative regulator of Mic10p oligomerization; Mic26p is a non-essential component of the complex; orthologous to human APOO and APOOL