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    COG1 Golgi transport complex subunit COG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COG1
    Official Full Name
    Golgi transport complex subunit COG1
    Primary source
    SGD:S000003191
    Locus tag
    YGL223C
    See related
    AllianceGenome:SGD:S000003191; FungiDB:YGL223C; VEuPathDB:YGL223C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COD3; LDB11; SEC36
    Summary
    Enables protein-macromolecule adaptor activity. Involved in Golgi organization; cytoplasm to vacuole targeting by the Cvt pathway; and retrograde transport, vesicle recycling within Golgi. Part of Golgi transport complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COG1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (79112..80365, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene GDP-mannose transporter Neighboring gene nucleotidase Neighboring gene Edc1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex. Chatterton JE, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927668, Free PMC Article
    2. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Shemorry A, et al. Mol Cell, 2013 May 23. PMID 23603116, Free PMC Article
    3. Molecular organization of the COG vesicle tethering complex. Lees JA, et al. Nat Struct Mol Biol, 2010 Nov. PMID 20972446, Free PMC Article
    4. Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. Fotso P, et al. J Biol Chem, 2005 Jul 29. PMID 15932880
    5. Molecular architecture of the complete COG tethering complex. Ha JY, et al. Nat Struct Mol Biol, 2016 Aug. PMID 27428773, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Cog1, a subunit of the Golgi-associated COG complex, is also shown to contain an Ac/N-degron interacts with Cog2, Cog3 and Cog4.
      Title: Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
    2. Cog1p has a critical role in the organization of the yeast conserved oligomeric Golgi complex
      Title: Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi transport complex subunit COG1
    NP_011292.1
    • Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      79112..80365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181088.1 → NP_011292.1  TPA: Golgi transport complex subunit COG1 [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVB2, P53079
      UniProtKB/TrEMBL
      C7GUZ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53079.1

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