GCR1 transcription regulator GCR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GCR1
Official Full Name: transcription regulator GCR1
Primary source: SGD:S000005996
Locus tag: YPL075W
See related: AllianceGenome:SGD:S000005996; FungiDB:YPL075W; VEuPathDB:YPL075W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPF10; SIT3
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in nucleosome organization; regulation of DNA-templated transcription; and regulation of glycolytic process. Located in nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GCR1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 2

Sequence:: Chromosome: XVI; NC_001148.4 (412254..415362)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impairment of transcription factor Gcr1p binding motif perturbs OPI3 transcription in Saccharomyces cerevisiae.
Title: Impairment of transcription factor Gcr1p binding motif perturbs OPI3 transcription in Saccharomyces cerevisiae.
GCR1 gene generates multiple protein isoforms, which are downregulated differentially upon glucose depletion.
Title: Posttranscriptional Regulation of Gcr1 Expression and Activity Is Crucial for Metabolic Adjustment in Response to Glucose Availability.
Gcr1 regulates the expression of PHO92, and Pho92 is involved in glucose metabolism.
Title: The expression of PHO92 is regulated by Gcr1, and Pho92 is involved in glucose metabolism in Saccharomyces cerevisiae.
study demonstrates that inositol pyrophosphates control the activity of the major glycolytic transcription factor GCR1
Title: Influence of inositol pyrophosphates on cellular energy dynamics.
Expression of GCR1, the transcriptional activator of glycolytic enzymes in the yeast Saccharomyces cerevisiae, is positively autoregulated by Gcr1p.
Title: Expression of GCR1, the transcriptional activator of glycolytic enzyme genes in the yeast Saccharomyces cerevisiae, is positively autoregulated by Gcr1p.
Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression.
Title: The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level.
Data show that Rap1/Gcr1/Gcr2 transcriptional activation in yeast cells occurs through a large anchored protein platform, the Nup84 nuclear pore subcomplex.
Title: Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription from a mobile element promoter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription regulator GCR1

NP_015250.1

Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; contains a long intron, which allows multiple RNA and protein isoforms with varying expression levels depending on glucose availability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

412254..415362

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183889.1 → NP_015250.1 TPA: transcription regulator GCR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015250.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3U1, P07261

UniProtKB/TrEMBL

C8ZIV5

Conserved Domains (2) summary

PHA03307
Location:362 → 616

PHA03307; transcriptional regulator ICP4; Provisional

pfam12550
Location:638 → 730

GCR1_C; Transcriptional activator of glycolytic enzymes