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    GDB1 bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856314, updated on 27-Dec-2024

    Summary

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    Official Symbol
    GDB1
    Official Full Name
    bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase
    Primary source
    SGD:S000006388
    Locus tag
    YPR184W
    See related
    AllianceGenome:SGD:S000006388; FungiDB:YPR184W; VEuPathDB:YPR184W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Involved in glycogen catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GDB1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (902044..906654)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SMX3 Neighboring gene dolichyl-phosphate beta-D-mannosyltransferase Neighboring gene serine/threonine protein kinase regulatory subunit ATG13 Neighboring gene Pzf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae YPR184w gene encodes the glycogen debranching enzyme. Teste MA, et al. FEMS Microbiol Lett, 2000 Dec 1. PMID 11094287
    2. Cyclization reaction catalyzed by glycogen debranching enzyme (EC 2.4.1.25/EC 3.2.1.33) and its potential for cycloamylose production. Yanase M, et al. Appl Environ Microbiol, 2002 Sep. PMID 12200270, Free PMC Article
    3. Association of bi-functional activity in the N-terminal domain of glycogen debranching enzyme. Min-Ho L, et al. Biochem Biophys Res Commun, 2014 Feb 28. PMID 24491554
    4. The Saccharomyces cerevisiae fermentation stress response protein Igd1p/Yfr017p regulates glycogen levels by inhibiting the glycogen debranching enzyme. Walkey CJ, et al. FEMS Yeast Res, 2011 Sep. PMID 21585652
    5. Data on dynamic study of cytoophidia in Saccharomyces cerevisiae. Li H, et al. Data Brief, 2016 Sep. PMID 27274529, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that the N-terminal domain (1-644) alone has both alpha-1,4-transferase and the alpha-1,6-glucosidase activities.
      Title: Association of bi-functional activity in the N-terminal domain of glycogen debranching enzyme.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4-alpha-glucanotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-alpha-glucanotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-alpha-glucanotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-alpha-glucanotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amylo-alpha-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amylo-alpha-1,6-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase
    NP_015510.1
    • Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      902044..906654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184281.1 → NP_015510.1  TPA: bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015510.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4I4, O93808, Q06625
      UniProtKB/TrEMBL
      A6ZX58, C7GP66, C8ZJL3
      Conserved Domains (1) summary
      TIGR01531
      Location:26 → 1528
      glyc_debranch; glycogen debranching enzymye
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06625.1

    Gene LinkOut

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