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    CG2003 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43761, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG2003provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039886
    Locus tag
    Dmel_CG2003
    See related
    AllianceGenome:FB:FBgn0039886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2003
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult head; embryonic/larval midgut primordium; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A1 (solute carrier family 17 member 1); SLC17A3 (solute carrier family 17 member 3); and SLC17A4 (solute carrier family 17 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2003 in Genome Data Viewer
    Location:
    100E1-100E1; 3-103 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31978121..31990909)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27803843..27816631)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 100F Neighboring gene Ferrochelatase Neighboring gene hephaestus Neighboring gene long non-coding RNA:CR45556 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic screen for genes involved in Chk2 signaling in Drosophila. Park SY, et al. Mol Cells, 2008 Oct 31. PMID 18612247
    2. Novel regulators revealed by profiling Drosophila testis stem cells within their niche. Terry NA, et al. Dev Biol, 2006 Jun 1. PMID 16616121
    3. Roles of major facilitator superfamily transporters in phosphate response in Drosophila. Bergwitz C, et al. PLoS One, 2012. PMID 22359624, Free PMC Article
    4. LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila. Marcogliese PC, et al. Hum Mol Genet, 2017 Apr 1. PMID 28158614, Free PMC Article
    5. Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. Raza Q, et al. PLoS Genet, 2019 Feb. PMID 30763317, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2003-PA
    CG2003-PB
    CG2003-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31978121..31990909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143646.5 → NP_651903.2  uncharacterized protein Dmel_CG2003, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651903.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYP2, Q9V9S4
      Related
      FBpp0085229
      Conserved Domains (2) summary
      cd06174
      Location:58 → 441
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:23 → 456
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    2. NM_001300702.1 → NP_001287631.1  uncharacterized protein Dmel_CG2003, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHY6
      Conserved Domains (1) summary
      cl28910
      Location:21 → 52
      MFS; Major Facilitator Superfamily

    3. NM_170584.3 → NP_733463.1  uncharacterized protein Dmel_CG2003, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYP2, Q9V9S4
      Related
      FBpp0085230
      Conserved Domains (2) summary
      cd06174
      Location:58 → 441
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:23 → 456
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHY6 A0A0B4LHY6
    Q8SYP2 Q8SYP2
    Q9V9S4 Q9V9S4

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