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    TRP1 phosphoribosylanthranilate isomerase TRP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851570, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRP1
    Official Full Name
    phosphoribosylanthranilate isomerase TRP1
    Primary source
    SGD:S000002414
    Locus tag
    YDR007W
    See related
    AllianceGenome:SGD:S000002414; FungiDB:YDR007W; VEuPathDB:YDR007W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoribosylanthranilate isomerase activity. Involved in tryptophan biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (461842..462516)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase III-inhibiting protein MAF1 Neighboring gene Sok1p Neighboring gene transcriptional regulator GAL3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A review of phenotypes in Saccharomyces cerevisiae. Hampsey M. Yeast, 1997 Sep 30. PMID 9301019
    2. Multiple control elements in the TRP1 promoter of Saccharomyces cerevisiae. Kim S, et al. Mol Cell Biol, 1986 Dec. PMID 3025648, Free PMC Article
    3. Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae. Perfect JR, et al. Gene, 1992 Dec 1. PMID 1452032
    4. Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene. Tschumper G, et al. Gene, 1980 Jul. PMID 6248420
    5. Ethylzingerone, a Novel Compound with Antifungal Activity. Rossignol T, et al. Antimicrob Agents Chemother, 2021 Mar 18. PMID 33468481, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylanthranilate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tryptophan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    phosphoribosylanthranilate isomerase TRP1
    NP_010290.3
    • Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); enhances vegetative growth at low and high temperatures when used as an auxotrophic marker in strains such as W303

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      461842..462516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180315.3 → NP_010290.3  TPA: phosphoribosylanthranilate isomerase TRP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010290.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRZ5, P00912, Q03448, Q12131, Q70DA4, Q70DA7, Q70DB2, Q7LHE0
      UniProtKB/TrEMBL
      A6ZXX3, B3LGQ1, B5VFR6, C7GXY3, C8Z4S7, G2WAB5, K4HWW7, K4HWY4, K4HWY8, K4HZS4, K4I8G4, K4I8J0, N1P607
      Conserved Domains (1) summary
      pfam00697
      Location:24 → 220
      PRAI; N-(5'phosphoribosyl)anthranilate (PRA) isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00912.2

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