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    TFB6 TFIIH complex subunit TFB6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TFB6
    Official Full Name
    TFIIH complex subunit TFB6
    Primary source
    SGD:S000005879
    Locus tag
    YOR352W
    See related
    AllianceGenome:SGD:S000005879; FungiDB:YOR352W; VEuPathDB:YOR352W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in cytoplasm and nucleus. Part of transcription factor TFIIH holo complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TFB6 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (997213..998244)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mne1p Neighboring gene serine/threonine protein kinase MEK1 Neighboring gene Sog2p Neighboring gene Msc6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of gene expression by a metabolic enzyme. Hall DA, et al. Science, 2004 Oct 15. PMID 15486299
    2. Function of Conserved Topological Regions within the Saccharomyces cerevisiae Basal Transcription Factor TFIIH. Warfield L, et al. Mol Cell Biol, 2016 Oct 1. PMID 27381459, Free PMC Article
    3. Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation. Murakami K, et al. Proc Natl Acad Sci U S A, 2012 Mar 27. PMID 22411836, Free PMC Article
    4. Structure of an RNA polymerase II preinitiation complex. Murakami K, et al. Proc Natl Acad Sci U S A, 2015 Nov 3. PMID 26483468, Free PMC Article
    5. Architecture of an RNA polymerase II transcription pre-initiation complex. Murakami K, et al. Science, 2013 Nov 8. PMID 24072820, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TFIIH complex subunit TFB6
    NP_014997.1
    • Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      997213..998244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183772.1 → NP_014997.1  TPA: TFIIH complex subunit TFB6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014997.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W347, Q08816
      UniProtKB/TrEMBL
      A6ZPI2, B3LK09, C7GNR6, C8ZHA3, G2WNL3, N1P3V7
      Conserved Domains (1) summary
      pfam17110
      Location:164 → 334
      TFB6; Subunit 11 of the general transcription factor TFIIH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08816.1

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