slpr slipper [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: slprprovided by FlyBase
Official Full Name: slipperprovided by FlyBase
Primary source: FLYBASE:FBgn0030018
Locus tag: Dmel_CG2272
See related: AllianceGenome:FB:FBgn0030018
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2; Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr
Summary: Enables JUN kinase kinase kinase activity. Involved in several processes, including cellular response to ethanol; dorsal appendage formation; and imaginal disc morphogenesis. Located in cell cortex. Is expressed in adult head; adult thorax; and organism. Orthologous to several human genes including MAP3K11 (mitogen-activated protein kinase kinase kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 7D17-7D17; 1-22 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8170229..8177185, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8064262..8071218, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila.
Title: Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila.
Slpr is dispensable for Eiger/TNF-induced cell death and innate immune response mediated by Tak1
Title: Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila.
PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.
Title: The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
a posttranslational modification on Slpr, at a conserved site among MAP3K mixed lineage kinase family members, which bolsters stress resistance with negligible effects on JNK-dependent developmental proces
Title: Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif.
The N-terminal half of Slpr is involved in regulating JNK signaling.
Title: Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.
evidence that dMLK/slipper can be classified as a MAPKKK family member in the activation of the JNK pathway
Title: Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.
activated by ceramide
Title: Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.
SLPR overexpression can induce ectopic Jun-N-terminal kinase kinase signaling; SLPR protein is enriched at the epithelial cell cortex.
Title: Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables MAP kinase kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in dorsal closure, elongation of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived female genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: slipper

Names: CG2272-PA; CG2272-PB; CG2272-PC; CG2272-PD; mixed lineage protein kinase 2; slpr-PA; slpr-PB; slpr-PC; slpr-PD

NP_001188558.1

EC 2.7.11.25

NP_001188559.1

EC 2.7.11.25

NP_001188560.1

EC 2.7.11.25

NP_572458.3

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8170229..8177185 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201630.2 → NP_001188559.1 slipper, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188559.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRK7, Q95UN8, Q95VF6, Q9W3I3

UniProtKB/TrEMBL

H1UUR7, M9MS26

Conserved Domains (3) summary

smart00219
Location:129 → 386

TyrKc; Tyrosine kinase, catalytic domain

cd11876
Location:47 → 104

SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases

cd14061
Location:134 → 389

STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases
NM_001201631.2 → NP_001188560.1 slipper, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188560.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRK7, Q95UN8, Q95VF6, Q9W3I3

UniProtKB/TrEMBL

H1UUR7, M9MS26

Conserved Domains (3) summary

smart00219
Location:129 → 386

TyrKc; Tyrosine kinase, catalytic domain

cd11876
Location:47 → 104

SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases

cd14061
Location:134 → 389

STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases
NM_132230.4 → NP_572458.3 slipper, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572458.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRK7, Q95UN8, Q95VF6, Q9W3I3

UniProtKB/TrEMBL

H1UUR7, M9MS26

Conserved Domains (3) summary

smart00219
Location:129 → 386

TyrKc; Tyrosine kinase, catalytic domain

cd11876
Location:47 → 104

SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases

cd14061
Location:134 → 389

STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases
NM_001201629.2 → NP_001188558.1 slipper, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188558.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRK7, Q95UN8, Q95VF6, Q9W3I3

UniProtKB/TrEMBL

H1UUR7, M9MSN2

Conserved Domains (3) summary

smart00219
Location:129 → 386

TyrKc; Tyrosine kinase, catalytic domain

cd11876
Location:47 → 104

SH3_MLK; Src Homology 3 domain of Mixed Lineage Kinases

cd14061
Location:134 → 389

STKc_MLK; Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases