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    Trc8 TRC8 ring finger protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trc8provided by FlyBase
    Official Full Name
    TRC8 ring finger proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039668
    Locus tag
    Dmel_CG2304
    See related
    AllianceGenome:FB:FBgn0039668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2304; Dmel\CG2304; Dtrc8; DTrc8; trc8; TRC8
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of growth and ventral midline development. Located in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human RNF139 (ring finger protein 139). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trc8 in Genome Data Viewer
    Location:
    99B1-99B1; 3-99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29499025..29503797, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25324747..25329519, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene diedel Neighboring gene F-box involved in polyQ pathogenesis Neighboring gene NADH dehydrogenase (ubiquinone) 20 kDa subunit-like Neighboring gene long non-coding RNA:CR43613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. msh specifies dorsal cell fate in the Drosophila wing. Milán M, et al. Development, 2001 Sep. PMID 11546743
    2. Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. Gemmill RM, et al. Oncogene, 2005 May 12. PMID 15735686
    3. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Gemmill RM, et al. Oncogene, 2002 May 16. PMID 12032852
    4. An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation. Kim M, et al. PLoS Genet, 2018 Feb. PMID 29420631, Free PMC Article
    5. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ventral midline development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TRC8 ring finger protein
    Names
    CG2304-PA
    CG2304-PB
    CG2304-PD
    CG2304-PE
    TRC8 ortholog
    Trc8-PA
    Trc8-PB
    Trc8-PD
    Trc8-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29499025..29503797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276141.1 → NP_001263070.1  TRC8 ring finger protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3L3
      Conserved Domains (3) summary
      pfam12678
      Location:613 → 654
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:614 → 654
      zf-RING_2; Ring finger domain
      pfam13705
      Location:122 → 585
      TRC8_N; TRC8 N-terminal domain

    2. NM_170414.2 → NP_733293.1  TRC8 ring finger protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3L3
      Related
      FBpp0084798
      Conserved Domains (3) summary
      pfam12678
      Location:613 → 654
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:614 → 654
      zf-RING_2; Ring finger domain
      pfam13705
      Location:122 → 585
      TRC8_N; TRC8 N-terminal domain

    3. NM_206580.2 → NP_996303.1  TRC8 ring finger protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996303.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KRW0, Q7KRW1, Q8IHG9, Q8MQX1, Q8T0E3, Q8WRY2, Q9VAK6
      Conserved Domains (3) summary
      pfam12678
      Location:618 → 659
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:619 → 659
      zf-RING_2; Ring finger domain
      pfam13705
      Location:122 → 590
      TRC8_N; TRC8 N-terminal domain

    4. NM_170413.3 → NP_733292.1  TRC8 ring finger protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733292.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3L3
      Related
      FBpp0084797
      Conserved Domains (3) summary
      pfam12678
      Location:613 → 654
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:614 → 654
      zf-RING_2; Ring finger domain
      pfam13705
      Location:122 → 585
      TRC8_N; TRC8 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V3L3 A4V3L3
    Q7KRW1.1 Q7KRW1

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