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    proX glycine betaine/carnitine/choline/L-proline ABC transporter substrate-binding lipoprotein ProX [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886270, updated on 17-Dec-2024

    Summary

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    Gene symbol
    proX
    Gene description
    glycine betaine/carnitine/choline/L-proline ABC transporter substrate-binding lipoprotein ProX
    Locus tag
    Rv3759c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (4204426..4205373, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene glycine betaine/carnitine/choline/L-proline ABC transporter permease ProZ Neighboring gene glycine betaine/carnitine/choline/L-proline ABC transporter permease ProW Neighboring gene glycine betaine/carnitine/choline/L-proline ABC transporter ATP-binding protein ProV Neighboring gene membrane protein Neighboring gene acyl-CoA dehydrogenase FadE36

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The putative compatible solute-binding protein ProX from Mycobacterium tuberculosis H37Rv: biochemical characterization and crystallographic data. Zhao JH, et al. Acta Crystallogr F Struct Biol Commun, 2018 Apr 1. PMID 29633971, Free PMC Article
    2. Glycine betaine uptake by the ProXVWZ ABC transporter contributes to the ability of Mycobacterium tuberculosis to initiate growth in human macrophages. Price CT, et al. J Bacteriol, 2008 Jun. PMID 18390665, Free PMC Article
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assuming the presence of two MtProX molecules in the asymmetric unit, the Matthews coefficient was calculated to be 2.74 A(3) Da(-1), which corresponds to a solvent content of 55%
      Title: The putative compatible solute-binding protein ProX from Mycobacterium tuberculosis H37Rv: biochemical characterization and crystallographic data.
    2. role of proXVWZ in allowing M. tuberculosis to obtain betaine from host macrophages and thereby contributes to early steps in colonizing this niche is reported
      Title: Glycine betaine uptake by the ProXVWZ ABC transporter contributes to the ability of Mycobacterium tuberculosis to initiate growth in human macrophages.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    glycine betaine/carnitine/choline/L-proline ABC transporter substrate-binding lipoprotein ProX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      4204426..4205373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218276.1 glycine betaine/carnitine/choline/L-proline ABC transporter substrate-binding lipoprotein ProX [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218276.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3LFN6
      Conserved Domains (1) summary
      cd13606
      Location:42 → 305
      PBP2_ProX_like; Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold
    Nucleotide Protein
    Heading Accession and Version

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