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    CG2887 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2887provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030207
    Locus tag
    Dmel_CG2887
    See related
    AllianceGenome:FB:FBgn0030207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2887
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Orthologous to human DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2887 in Genome Data Viewer
    Location:
    9D1-9D1; 1-32 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10477260..10478493, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10371293..10372526, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Neb-cGP Neighboring gene no circadian temperature entrainment Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 4 regulatory subunit 2-related protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes. Lee H, et al. Mol Cell Biol, 2012 Jun. PMID 22451490, Free PMC Article
    2. A role for the chaperone Hsp70 in the regulation of border cell migration in the Drosophila ovary. Cobreros L, et al. Mech Dev, 2008 Nov-Dec. PMID 18718532
    3. A rapidly evolving MYB-related protein causes species isolation in Drosophila. Barbash DA, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12695567, Free PMC Article
    4. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Kuo Y, et al. Cell Death Dis, 2013 Oct 3. PMID 24091676, Free PMC Article
    5. Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. Lee H, et al. Mol Cell Biol, 2010 May. PMID 20176807, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2887-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10477260..10478493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132405.3 → NP_572633.1  uncharacterized protein Dmel_CG2887 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2U5
      Related
      FBpp0071393
      Conserved Domains (3) summary
      cd10747
      Location:163 → 326
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 331
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2U5 Q9W2U5

    Gene LinkOut

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