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    Oatp58Db Organic anion transporting polypeptide 58Db [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oatp58Dbprovided by FlyBase
    Official Full Name
    Organic anion transporting polypeptide 58Dbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034715
    Locus tag
    Dmel_CG3382
    See related
    AllianceGenome:FB:FBgn0034715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    58Db; CG3382; Dmel\CG3382; EcI-4; oatp 58Db
    Summary
    Enables organic anion transmembrane transporter activity. Involved in organic anion transport; renal tubular secretion; and transmembrane transport. Located in basolateral plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder; gastrointestinal stromal tumor; and primary hypertrophic osteoarthropathy. Orthologous to several human genes including SLCO1A2 (solute carrier organic anion transporter family member 1A2); SLCO1B1 (solute carrier organic anion transporter family member 1B1); and SLCO1B3 (solute carrier organic anion transporter family member 1B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oatp58Db in Genome Data Viewer
    Location:
    58D2-58D2; 2-99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22221180..22223499, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18108685..18111095, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ariadne 2 Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 58Da Neighboring gene Organic anion transporting polypeptide 58Dc Neighboring gene long non-coding RNA:CR44755

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides. Groen SC, et al. Insect Biochem Mol Biol, 2017 Feb. PMID 28011348, Free PMC Article
    2. Essential functions of mosquito ecdysone importers in development and reproduction. Hun LV, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696563, Free PMC Article
    3. Resolution of the insect ouabain paradox. Torrie LS, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15347816, Free PMC Article
    4. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 33163493, Free PMC Article
    5. An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in Drosophila. Santabárbara-Ruiz P, et al. Dev Cell, 2021 Oct 11. PMID 34610327

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in renal tubular secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    organic anion transporting polypeptide 58Db
    Names
    CG3382-PB
    Oatp58Db-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22221180..22223499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137814.4 → NP_611658.3  organic anion transporting polypeptide 58Db [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVL1, Q9W270
      Conserved Domains (3) summary
      cd06174
      Location:55 → 410
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:447 → 499
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:53 → 619
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W270 Q9W270

    Gene LinkOut

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