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    Nplp1 Neuropeptide-like precursor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38003, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Nplp1provided by FlyBase
    Official Full Name
    Neuropeptide-like precursor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035092
    Locus tag
    Dmel_CG3441
    See related
    AllianceGenome:FB:FBgn0035092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    APK; CG3441; Dmel\CG3441; IPNa; IPNamide; MTY-amide; MTYa; MTYamide; NPLP-1; nplp1; NPLP1; VQQ
    Summary
    Enables neuropeptide hormone activity. Involved in receptor guanylyl cyclase signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including DN1a neurons; anterior-posterior subdivision of organism; brain; embryonic central brain neurons; and larval neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nplp1 in Genome Data Viewer
    Location:
    60F1-60F1; 2-107 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25032377..25040377)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20919900..20927900)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene zipper Neighboring gene unzipped Neighboring gene gooseberry-neuro Neighboring gene gooseberry

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of a novel neuropeptide, NVGTLARDFQLPIPNamide, in the larval and adult brain of Drosophila melanogaster. Verleyen P, et al. J Neurochem, 2004 Jan. PMID 14690519
    2. Combinatorial coding for Drosophila neurons. Jones R. PLoS Biol, 2007 Feb. PMID 20076660, Free PMC Article
    3. Peptidomics of CNS-associated neurohemal systems of adult Drosophila melanogaster: a mass spectrometric survey of peptides from individual flies. Predel R, et al. J Comp Neurol, 2004 Jun 28. PMID 15174081
    4. Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes. Shafer OT, et al. J Comp Neurol, 2006 Sep 10. PMID 16856134, Free PMC Article
    5. Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. Carlsson MA, et al. J Comp Neurol, 2010 Aug 15. PMID 20575072

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nplp1 neuropeptide neurons in the developing Drosophila nerve cord belong to two sub-classes; Tv1 and dAp neurons, generated by two distinct progenitors. Nplp1 neurons are specified by spatial cues
      Title: Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables receptor ligand activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Neuropeptide-like precursor 1
    Names
    APK peptide
    CG3441-PA
    CG3441-PB
    CG3441-PC
    IPNamide
    IPNamide peptide
    MTYamide peptide
    Nplp1-PA
    Nplp1-PB
    Nplp1-PC
    neuropeptide like precursor 1
    neuropeptide like precursor protein 1
    neuropeptide-like precursor 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      25032377..25040377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144288.2 → NP_001137760.1  Neuropeptide-like precursor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZQ9

    2. NM_001043105.3 → NP_001036570.1  Neuropeptide-like precursor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8W0

    3. NM_138149.3 → NP_611993.1  Neuropeptide-like precursor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95T41, Q9W0W6
      Related
      FBpp0072348
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZQ9 B7YZQ9
    Q0E8W0 Q0E8W0
    Q9W0W6.2 Q9W0W6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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