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    Trx2 Thioredoxin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34281, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trx2provided by FlyBase
    Official Full Name
    Thioredoxin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0040070
    Locus tag
    Dmel_CG31884
    See related
    AllianceGenome:FB:FBgn0040070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    31884; anon-WO0118547.188; CG31884; CG3864; DmelTrx-2; Dmel\CG31884; dmtrx-2; DmTrx-2; DTrx-2; Trx; trx-2; Trx-2; TRX2
    Summary
    Enables glutathione disulfide oxidoreductase activity. Involved in several processes, including cell redox homeostasis; defense response to fungus; and determination of adult lifespan. Located in nucleus. Is expressed in adult head; adult heart; imaginal disc; and primary spermatocyte. Orthologous to several human genes including TXN (thioredoxin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Trx2 in Genome Data Viewer
    Location:
    30C1-30C1; 2-36 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9613166..9616404)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9613166..9616404)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene gcm2 Neighboring gene Glucuronyltransferase S Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    thioredoxin 2
    Names
    CG31884-PA
    CG31884-PB
    Trx2-PA
    Trx2-PB
    thioredoxin
    thioredoxin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9613166..9616404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164863.3NP_723475.1  thioredoxin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H9, D3DMZ9, Q95SW4, Q9V429
      Related
      FBpp0079436
      Conserved Domains (1) summary
      cd02947
      Location:18103
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    2. NM_078802.4NP_523526.1  thioredoxin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523526.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0H9, D3DMZ9, Q95SW4, Q9V429
      Related
      FBpp0079437
      Conserved Domains (1) summary
      cd02947
      Location:18103
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...