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    Nf-YA Nuclear factor Y-box A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nf-YAprovided by FlyBase
    Official Full Name
    Nuclear factor Y-box Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035993
    Locus tag
    Dmel_CG3891
    See related
    AllianceGenome:FB:FBgn0035993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3891; Dmel\CG3891; dNF-YA; NF-YA
    Summary
    Enables transcription cis-regulatory region binding activity. Contributes to sequence-specific DNA binding activity. Involved in R7 cell differentiation and positive regulation of DNA-templated transcription. Part of CCAAT-binding activity factor complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nf-YA in Genome Data Viewer
    Location:
    67B6-67B6; 3-29 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9440056..9442267, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9433156..9435367, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Metal response element-binding Transcription Factor-1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45872 Neighboring gene Blocked early in transport 3 Neighboring gene Sting-regulated gene 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NF-Y transcriptionally regulates the Drosophila p53 gene. Tue NT, et al. Gene, 2011 Feb 15. PMID 21044877
    2. Drosophila transcription factor NF-Y suppresses transcription of the lipase 4 gene, a key gene for lipid storage. Yoshioka Y, et al. Exp Cell Res, 2022 Nov 1. PMID 36028059
    3. Transcription factor NF-Y is involved in regulation of the JNK pathway during Drosophila thorax development. Yoshioka Y, et al. Genes Cells, 2008 Feb. PMID 18233955
    4. Transcription factor NF-Y is involved in differentiation of R7 photoreceptor cell in Drosophila. Yoshioka Y, et al. Biol Open, 2012 Jan 15. PMID 23213364, Free PMC Article
    5. Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock. Zhu B, et al. Front Physiol, 2023. PMID 37324401, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCAAT-binding factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor Y-box A
    Names
    CG3891-PA
    Nf-YA-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9440056..9442267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140056.3 → NP_648313.1  nuclear factor Y-box A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSY9
      Related
      FBpp0076232
      Conserved Domains (1) summary
      smart00521
      Location:286 → 345
      CBF; CCAAT-Binding transcription Factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSY9 Q9VSY9

    Gene LinkOut

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