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    CG4036 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4036provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032149
    Locus tag
    Dmel_CG4036
    See related
    AllianceGenome:FB:FBgn0032149
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4036
    Summary
    Predicted to enable broad specificity oxidative DNA demethylase activity. Involved in larval lymph gland hemopoiesis. Predicted to be active in contractile ring and midbody. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and embryonic/larval posterior spiracle. Orthologous to human ALKBH4 (alkB homolog 4, lysine demethylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4036 in Genome Data Viewer
    Location:
    30D1-30D1; 2-36 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9790882..9791958)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9790882..9791958)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pickpocket 11 Neighboring gene pickpocket 16 Neighboring gene hairpin RNA:CR18854 Neighboring gene Inositol 1,4,5-triphosphate kinase 1 Neighboring gene nicotinic Acetylcholine Receptor alpha6 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs. Muraoka Y, et al. Exp Neurol, 2018 Dec. PMID 30165075
    2. Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. Mondal BC, et al. Elife, 2014 Sep 8. PMID 25201876, Free PMC Article
    3. Drosophila models to study causative genes for human rare intractable neurological diseases. Yamaguchi M, et al. Exp Cell Res, 2021 Jun 1. PMID 33812867
    4. Evolution of alternative splicing in newly evolved genes of Drosophila. Zhan Z, et al. Gene, 2011 Jan 1. PMID 20851753
    5. Comparative genomics and evolution of proteins involved in RNA metabolism. Anantharaman V, et al. Nucleic Acids Res, 2002 Apr 1. PMID 11917006, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-oxoglutarate-dependent dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables broad specificity oxidative DNA demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in demethylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4036-PA
    CG4036-PB
    NP_001188762.1
    NP_609314.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9790882..9791958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201833.1 → NP_001188762.1  uncharacterized protein Dmel_CG4036, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR16, Q9VL81
      Conserved Domains (1) summary
      cl01206
      Location:73 → 190
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. NM_135470.3 → NP_609314.1  uncharacterized protein Dmel_CG4036, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR16, Q9VL81
      Related
      FBpp0079466
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR16 Q8MR16
    Q9VL81 Q9VL81

    Gene LinkOut

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