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    CG4650 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34859, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG4650provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032549
    Locus tag
    Dmel_CG4650
    See related
    AllianceGenome:FB:FBgn0032549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4650; SPH197
    Summary
    Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4650 in Genome Data Viewer
    Location:
    35B5-35B5; 2-50 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14773814..14774981, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14773814..14774981, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 1a Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microarray analysis of immune challenged Drosophila hemocytes. Johansson KC, et al. Exp Cell Res, 2005 Apr 15. PMID 15777795
    2. New components of Drosophila leg development identified through genome wide association studies. Grubbs N, et al. PLoS One, 2013. PMID 23560084, Free PMC Article
    3. Impact of tRNA-induced proline-to-serine mistranslation on the transcriptome of Drosophila melanogaster. Isaacson JR, et al. G3 (Bethesda), 2024 Sep 4. PMID 38989890, Free PMC Article
    4. Microarray analysis and organization of circadian gene expression in Drosophila. McDonald MJ, et al. Cell, 2001 Nov 30. PMID 11733057
    5. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4650-PB
    CG4650-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14773814..14774981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299014.1 → NP_001285943.1  uncharacterized protein Dmel_CG4650, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAH5
      Conserved Domains (1) summary
      cl21584
      Location:33 → 86
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_135878.3 → NP_609722.2  uncharacterized protein Dmel_CG4650, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609722.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS70, Q9VJR8
      Conserved Domains (2) summary
      smart00020
      Location:33 → 258
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:33 → 258
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS70 Q8MS70
    Q9VJR8 Q9VJR8
    X2JAH5 X2JAH5

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