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    vret vreteno [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vretprovided by FlyBase
    Official Full Name
    vretenoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263143
    Locus tag
    Dmel_CG4771
    See related
    AllianceGenome:FB:FBgn0263143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4771; Dmel\CG4771; Vret
    Summary
    Involved in oogenesis; primary piRNA processing; and secondary piRNA processing. Located in P granule and cytosol. Is active in Yb body. Is expressed in organism; ovary; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vret in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22742954..22745581, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18568676..18571303, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tak1-like 2 Neighboring gene Dicer-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1c Neighboring gene uncharacterized protein Neighboring gene rumi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirements for multivalent Yb body assembly in transposon silencing in Drosophila. Hirakata S, et al. EMBO Rep, 2019 Jul. PMID 31267711, Free PMC Article
    2. A novel transposable element-mediated mechanism causes antiviral resistance in Drosophila through truncating the Veneno protein. Brosh O, et al. Proc Natl Acad Sci U S A, 2022 Jul 19. PMID 35858337, Free PMC Article
    3. Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia. Fort-Aznar L, et al. Hum Mol Genet, 2020 Sep 29. PMID 32628265, Free PMC Article
    4. Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila. Zamparini AL, et al. Development, 2011 Sep. PMID 21831924, Free PMC Article
    5. piRNAs as Modulators of Disease Pathogenesis. Rayford KJ, et al. Int J Mol Sci, 2021 Feb 27. PMID 33673453, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary piRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in secondary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Yb body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Yb body IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vreteno
    Names
    CG4771-PA
    avocado
    vret-PA
    vretano

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22742954..22745581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142835.4 → NP_651092.1  vreteno [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCU7
      Related
      FBpp0083716
      Conserved Domains (2) summary
      cd04508
      Location:577 → 622
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:520 → 640
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCU7.1 Q9VCU7

    Gene LinkOut

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