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    Ugt303A1 UDP-glycosyltransferase family 303 member A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53503, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt303A1provided by FlyBase
    Official Full Name
    UDP-glycosyltransferase family 303 member A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040252
    Locus tag
    Dmel_CG4772
    See related
    AllianceGenome:FB:FBgn0040252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 006491H; CG4772; Dmel\CG4772; UGT303A1; Ugt86Dh
    Summary
    Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ugt303A1 in Genome Data Viewer
    Location:
    86D6-86D6; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11175529..11177910)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7001251..7003632)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 35 member A1 Neighboring gene UDP-glycosyltransferase family 304 member A1 Neighboring gene uncharacterized protein Neighboring gene curled

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Naturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance in Drosophila melanogaster. Highfill CA, et al. Genetics, 2017 Sep. PMID 28743761, Free PMC Article
    2. Natural selection shapes genome-wide patterns of copy-number polymorphism in Drosophila melanogaster. Emerson JJ, et al. Science, 2008 Jun 20. PMID 18535209
    3. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article
    4. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
    5. Insect glycobiology: a lectin multigene family in Drosophila melanogaster. Theopold U, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441526

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glycosyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycosylation ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glycosyltransferase family 303 member A1
    Names
    CG4772-PA
    CG4772-PB
    UDP-glycosyltransferase 86Dh
    Ugt303A1-PA
    Ugt303A1-PB
    Ugt86Dh

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11175529..11177910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275541.1 → NP_001262470.1  UDP-glycosyltransferase family 303 member A1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLS6, Q9VGS7
      Conserved Domains (2) summary
      PHA03392
      Location:26 → 465
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:39 → 507
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    2. NM_144364.2 → NP_652621.1  UDP-glycosyltransferase family 303 member A1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLS6, Q9VGS7
      Related
      FBpp0081816
      Conserved Domains (2) summary
      PHA03392
      Location:26 → 465
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:39 → 507
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGS7 Q9VGS7

    Gene LinkOut

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