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    AdipoR Adiponectin receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42656, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AdipoRprovided by FlyBase
    Official Full Name
    Adiponectin receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038984
    Locus tag
    Dmel_CG5315
    See related
    AllianceGenome:FB:FBgn0038984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5315; dAdipoR; Dmel\CG5315
    Summary
    Predicted to enable protein-hormone receptor activity. Involved in several processes, including female germ-line stem cell population maintenance; positive regulation of insulin secretion; and triglyceride homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and larval circulatory system. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; metabolic dysfunction-associated steatotic liver disease; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including ADIPOR1 (adiponectin receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AdipoR in Genome Data Viewer
    Location:
    94B3-94B3; 3-75 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22543693..22547846, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18369415..18373568, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45646 Neighboring gene long non-coding RNA:CR45647 Neighboring gene antisense RNA:CR44062 Neighboring gene james bond Neighboring gene stuck in traffic

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Brain adiponectin signaling controls peripheral insulin response in Drosophila. Arquier N, et al. Nat Commun, 2021 Sep 24. PMID 34561451, Free PMC Article
    2. Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion. Kwak SJ, et al. PLoS One, 2013. PMID 23874700, Free PMC Article
    3. Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance. Laws KM, et al. Dev Biol, 2015 Mar 15. PMID 25576925, Free PMC Article
    4. Regulation of adult female germline stem cells by nutrient-responsive signaling. Lin KY, et al. Curr Opin Insect Sci, 2020 Feb. PMID 32070932
    5. A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Szafer-Glusman E, et al. Curr Biol, 2008 Sep 23. PMID 18804373, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brain adiponectin signaling controls peripheral insulin response in Drosophila.
      Title: Brain adiponectin signaling controls peripheral insulin response in Drosophila.
    2. There is an intrinsic requirement for AdipoR in germline stem cell maintenance in the Drosophila ovary.
      Title: Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adiponectin receptor
    Names
    AdipoR-PA
    AdipoR-PB
    AdipoR-PC
    AdipoR-PD
    AdipoR-PE
    CG5315-PA
    CG5315-PB
    CG5315-PC
    CG5315-PD
    CG5315-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22543693..22547846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142804.3 → NP_651061.1  adiponectin receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651061.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCY8, Q9VCY9
      UniProtKB/TrEMBL
      A4V392
      Related
      FBpp0083675
      Conserved Domains (1) summary
      pfam03006
      Location:198 → 419
      HlyIII; Haemolysin-III related

    2. NM_170019.2 → NP_732758.1  adiponectin receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732758.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCY8, Q9VCY9
      UniProtKB/TrEMBL
      A4V392
      Related
      FBpp0083676
      Conserved Domains (1) summary
      pfam03006
      Location:198 → 419
      HlyIII; Haemolysin-III related

    3. NM_001260310.2 → NP_001247239.1  adiponectin receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCY8, Q9VCY9
      UniProtKB/TrEMBL
      A4V392
      Conserved Domains (1) summary
      pfam03006
      Location:198 → 419
      HlyIII; Haemolysin-III related

    4. NM_001275915.1 → NP_001262844.1  adiponectin receptor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCY8, Q9VCY9
      UniProtKB/TrEMBL
      A4V392
      Conserved Domains (1) summary
      pfam03006
      Location:198 → 419
      HlyIII; Haemolysin-III related

    5. NM_170020.2 → NP_732759.2  adiponectin receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732759.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP81
      Related
      FBpp0083677
      Conserved Domains (1) summary
      pfam03006
      Location:116 → 337
      HlyIII; Haemolysin-III related
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V392 A4V392
    Q9VCY8.2 Q9VCY8

    Gene LinkOut

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