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    INTS5 integrator complex subunit 5 [ Homo sapiens (human) ]

    Gene ID: 80789, updated on 27-Dec-2024

    Summary

    Official Symbol
    INTS5provided by HGNC
    Official Full Name
    integrator complex subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:29352
    See related
    Ensembl:ENSG00000185085 MIM:611349; AllianceGenome:HGNC:29352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT5; KIAA1698
    Summary
    The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 6.3), thyroid (RPKM 6.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See INTS5 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62646848..62653302, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62636300..62642755, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62414320..62420774, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384118-62384618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384619-62385119 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62388711-62389304 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62391987-62392312 Neighboring gene glucosidase II alpha subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62412284-62413091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62420185-62420944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4834 Neighboring gene chromosome 11 open reading frame 98 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene citrate synthase lysine methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: LBHD1

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytosol  
    part_of integrator complex  
    part_of integrator complex PubMed 
    part_of integrator complex PubMed 
    located_in membrane PubMed 
    located_in nuclear membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    integrator complex subunit 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030628.2NP_085131.1  integrator complex subunit 5

      See identical proteins and their annotated locations for NP_085131.1

      Status: REVIEWED

      Source sequence(s)
      BC060841
      Consensus CDS
      CCDS8027.1
      UniProtKB/Swiss-Prot
      Q6P9B9, Q8N6W5, Q9C0G5
      Related
      ENSP00000327889.2, ENST00000330574.2
      Conserved Domains (2) summary
      pfam14837
      Location:29251
      INTS5_N; Integrator complex subunit 5 N-terminus
      pfam14838
      Location:290999
      INTS5_C; Integrator complex subunit 5 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62646848..62653302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62636300..62642755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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