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    MYO1F myosin IF [ Homo sapiens (human) ]

    Gene ID: 4542, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MYO1Fprovided by HGNC
    Official Full Name
    myosin IFprovided by HGNC
    Primary source
    HGNC:HGNC:7600
    See related
    Ensembl:ENSG00000142347 MIM:601480; AllianceGenome:HGNC:7600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
    Expression
    Biased expression in bone marrow (RPKM 41.2), spleen (RPKM 33.9) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYO1F in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8520778..8577442, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8508359..8564804, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8585662..8642326, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8563393-8564079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8570689-8571189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8571229-8571815 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8576283-8577173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8587561-8588060 Neighboring gene zinc finger protein 414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10031 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8590637-8591612 Neighboring gene uncharacterized LOC124904633 Neighboring gene MPRA-validated peak3335 silencer Neighboring gene MPRA-validated peak3337 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10033 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:8643658-8643852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8649461-8650040 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:8651198-8651775 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8656685-8657283 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:8674492-8674914 Neighboring gene Sharpr-MPRA regulatory region 9055 Neighboring gene NFIL3 like basic leucine zipper Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13924

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis. Navinés-Ferrer A, et al. J Immunol, 2021 May 15. PMID 33941653, Free PMC Article
    2. Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration. Navinés-Ferrer A, et al. Front Immunol, 2019. PMID 31143189, Free PMC Article
    3. Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis. Liu W, et al. Int Immunopharmacol, 2024 Dec 5. PMID 39276460
    4. Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer. Diquigiovanni C, et al. Int J Cancer, 2018 Oct 1. PMID 29672841
    5. Are MYO1C and MYO1F associated with hearing loss? Zadro C, et al. Biochim Biophys Acta, 2009 Jan. PMID 19027848

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis.
      Title: Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis.
    2. MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
      Title: MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
    3. Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration.
      Title: Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration.
    4. NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.
      Title: NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.
    5. Mutations in MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer.
      Title: Mutant MYO1F alters the mitochondrial network and induces tumor proliferation in thyroid cancer.
    6. identification of 6 heterozygous missense mutations in MYO1C and additional 5 heterozygous missense mutations in MYO1F in bilateral sensorineural hearing loss
      Title: Are MYO1C and MYO1F associated with hearing loss?
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Are MYO1C and MYO1F associated with hearing loss?
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of myosin IF (MYO1F) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables actin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of unconventional myosin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    unconventional myosin-If
    Names
    myosin-ID
    myosin-Ie

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052844.1 RefSeqGene

      Range
      5006..61670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348355.2 → NP_001335284.1  unconventional myosin-If isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC092298, AC092316, AC130469
      UniProtKB/TrEMBL
      B0I1T1
      Conserved Domains (4) summary
      cd11827
      Location:1041 → 1093
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      cd01378
      Location:31 → 673
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:713 → 911
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
      cl26464
      Location:954 → 1039
      Atrophin-1; Atrophin-1 family

    2. NM_012335.4 → NP_036467.2  unconventional myosin-If isoform 1

      See identical proteins and their annotated locations for NP_036467.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB210037, AC092298, BC028071, DA380582
      Consensus CDS
      CCDS42494.1
      UniProtKB/Swiss-Prot
      O00160, Q8WWN7
      UniProtKB/TrEMBL
      B0I1T1
      Related
      ENSP00000494550.1, ENST00000644032.2
      Conserved Domains (4) summary
      cd11827
      Location:1045 → 1097
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      cd01378
      Location:31 → 677
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:717 → 915
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
      cl26464
      Location:958 → 1043
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      8520778..8577442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528027.3 → XP_011526329.1  unconventional myosin-If isoform X2

      UniProtKB/TrEMBL
      B0I1T1
      Conserved Domains (4) summary
      cd11827
      Location:1021 → 1073
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      smart00242
      Location:12 → 666
      MYSc; Myosin. Large ATPases
      cl22853
      Location:31 → 653
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:693 → 873
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. XM_011528024.3 → XP_011526326.1  unconventional myosin-If isoform X1

      UniProtKB/TrEMBL
      B0I1T1
      Conserved Domains (4) summary
      cd11827
      Location:1066 → 1118
      SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins
      smart00242
      Location:12 → 711
      MYSc; Myosin. Large ATPases
      cd01378
      Location:31 → 698
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:738 → 918
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. XM_047438852.1 → XP_047294808.1  unconventional myosin-If isoform X3

    4. XM_011528028.4 → XP_011526330.1  unconventional myosin-If isoform X4

      Conserved Domains (2) summary
      smart00242
      Location:12 → 508
      MYSc; Myosin. Large ATPases
      cl22853
      Location:31 → 508
      Motor_domain; Myosin and Kinesin motor domain

    RNA

    1. XR_001753692.3 RNA Sequence

    2. XR_936182.4 RNA Sequence

    3. XR_936181.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      8508359..8564804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321055.1 → XP_054177030.1  unconventional myosin-If isoform X2

      UniProtKB/TrEMBL
      B0I1T1

    2. XM_054321054.1 → XP_054177029.1  unconventional myosin-If isoform X1

      UniProtKB/TrEMBL
      B0I1T1

    3. XM_054321056.1 → XP_054177031.1  unconventional myosin-If isoform X3

    4. XM_054321057.1 → XP_054177032.1  unconventional myosin-If isoform X4

    RNA

    1. XR_008485155.1 RNA Sequence

    2. XR_008485156.1 RNA Sequence

    3. XR_008485157.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00160.3 GenPept UniProtKB/Swiss-Prot:O00160

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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