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    FEZ2 fasciculation and elongation protein zeta 2 [ Homo sapiens (human) ]

    Gene ID: 9637, updated on 10-Dec-2024

    Summary

    Official Symbol
    FEZ2provided by HGNC
    Official Full Name
    fasciculation and elongation protein zeta 2provided by HGNC
    Primary source
    HGNC:HGNC:3660
    See related
    Ensembl:ENSG00000171055 MIM:604826; AllianceGenome:HGNC:3660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUM3CL
    Summary
    This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 32.7), brain (RPKM 29.1) and 24 other tissues See more
    Orthologs
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    Genomic context

    See FEZ2 in Genome Data Viewer
    Location:
    2p22.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (36552258..36598168, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (36556883..36604833, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (36779401..36825311, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:36607886-36608402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:36609434-36609948 Neighboring gene cysteine rich transmembrane BMP regulator 1 Neighboring gene uncharacterized LOC124905989 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:36676488-36677687 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:36685741-36686420 Neighboring gene Sharpr-MPRA regulatory region 272 Neighboring gene Sharpr-MPRA regulatory region 355 Neighboring gene Sharpr-MPRA regulatory region 14108 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:36734536-36735080 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:36788221-36789420 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:36824452-36825379 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:36825380-36826306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:36827234-36828159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15576 Neighboring gene Sharpr-MPRA regulatory region 2322 Neighboring gene RACK1 pseudogene 2 Neighboring gene uncharacterized LOC124905990 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:36964254-36964949 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:36981017-36981669 Neighboring gene vitrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15577

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC117372

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in axon  
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    fasciculation and elongation protein zeta-2
    Names
    pre-T/NK cell associated protein (3Cl)
    zygin 2
    zygin II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042548.2 → NP_001036013.1  fasciculation and elongation protein zeta-2 isoform 2

      See identical proteins and their annotated locations for NP_001036013.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1, resulting in a longer protein isoform.
      Source sequence(s)
      AC007401, BC089390
      Consensus CDS
      CCDS46258.1
      UniProtKB/TrEMBL
      Q0D2I6
      Related
      ENSP00000368547.4, ENST00000379245.8
      Conserved Domains (1) summary
      pfam07763
      Location:51 → 270
      FEZ; FEZ-like protein
    2. NM_005102.3 → NP_005093.2  fasciculation and elongation protein zeta-2 isoform 1

      See identical proteins and their annotated locations for NP_005093.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the more abundant transcript.
      Source sequence(s)
      AC007401, BC037566
      Consensus CDS
      CCDS46257.1
      UniProtKB/Swiss-Prot
      Q5EBN3, Q76LN0, Q99690, Q9UHY8
      UniProtKB/TrEMBL
      Q0D2I6
      Related
      ENSP00000385112.3, ENST00000405912.8
      Conserved Domains (1) summary
      pfam07763
      Location:51 → 270
      FEZ; FEZ-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      36552258..36598168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_244972.4 RNA Sequence

      Related
      ENST00000451623.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      36556883..36604833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344669.1 → XP_054200644.1  fasciculation and elongation protein zeta-2 isoform X1

      UniProtKB/TrEMBL
      F8W6C0

    RNA

    1. XR_008486604.1 RNA Sequence

    2. XR_008486605.1 RNA Sequence

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