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    CG7069 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42621, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7069provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038952
    Locus tag
    Dmel_CG7069
    See related
    AllianceGenome:FB:FBgn0038952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7069
    Summary
    Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R) and PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7069 in Genome Data Viewer
    Location:
    94A6-94A6; 3-74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22372835..22375579)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18198557..18201301)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit F Neighboring gene Pyruvate kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. Heidarian Y, et al. G3 (Bethesda), 2023 Dec 29. PMID 37792629, Free PMC Article
    2. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. Ding L, et al. EMBO J, 2018 Sep 3. PMID 30049710, Free PMC Article
    3. Quantitative trait loci for response to ethanol in an intercontinental set of recombinant inbred lines of Drosophila melanogaster. Defays R, et al. Alcohol, 2012 Dec. PMID 22925826
    4. Correlation between desiccation stress response and epigenetic modifications of genes in Drosophila melanogaster: An example of environment-epigenome interaction. Sharma V, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Oct. PMID 28801151
    5. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyruvate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7069-PA
    NP_651030.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22372835..22375579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142773.1 → NP_651030.1  uncharacterized protein Dmel_CG7069 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNW4, Q9VD23
      Related
      FBpp0083612, FBtr0084215
      Conserved Domains (2) summary
      PRK05826
      Location:1 → 446
      PRK05826; pyruvate kinase; Provisional
      cl23794
      Location:1 → 410
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD23 Q9VD23

    Gene LinkOut

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