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    CASC9 cancer susceptibility 9 [ Homo sapiens (human) ]

    Gene ID: 101805492, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CASC9provided by HGNC
    Official Full Name
    cancer susceptibility 9provided by HGNC
    Primary source
    HGNC:HGNC:48906
    See related
    Ensembl:ENSG00000249395 AllianceGenome:HGNC:48906
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESSCAL1; ESCCAL-1; LINC00981; linc-JPH1
    Expression
    Biased expression in colon (RPKM 1.7), placenta (RPKM 0.9) and 8 other tissues See more
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    Genomic context

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    See CASC9 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (75223117..75278889, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (75652630..75708379, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (76135352..76191124, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cysteine rich secretory protein LCCL domain containing 1 Neighboring gene uncharacterized LOC124901964 Neighboring gene uncharacterized LOC105375905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:76042510-76043087 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:76131164-76131759 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:76190151-76191350 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 6 Neighboring gene pyruvate kinase M1/2 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. CASC9 plays a role in salivary adenoid cystic carcinoma in vitro by upregulation of ACLY. Xie H, et al. Oral Dis, 2022 Mar. PMID 33345395
    2. Upregulation of the long non-coding RNA CASC9 as a biomarker for squamous cell carcinoma. Sassenberg M, et al. BMC Cancer, 2019 Aug 14. PMID 31412811, Free PMC Article
    3. GLUT-1 participates in the promotion of LncRNA CASC9 in proliferation and metastasis of laryngeal carcinoma cells. Xi J, et al. Gene, 2020 Feb 5. PMID 31669650
    4. Diagnostic and prognostic value of lncRNA cancer susceptibility candidate 9 in hepatocellular carcinoma. Zeng YL, et al. World J Gastroenterol, 2019 Dec 28. PMID 31908394, Free PMC Article
    5. Down-regulation of lncRNA CASC9 aggravates sepsis-induced acute lung injury by regulating miR-195-5p/PDK4 axis. Wang HR, et al. Inflamm Res, 2020 Jun. PMID 32221619

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-kappaB signaling pathway.
      Title: CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway.
    2. Long noncoding RNA CASC9 promotes pancreatic cancer progression by acting as a ceRNA of miR-497-5p to upregulate expression of CCND1.
      Title: Long noncoding RNA CASC9 promotes pancreatic cancer progression by acting as a ceRNA of miR-497-5p to upregulate expression of CCND1.
    3. LncRNA CASC9 promotes cell proliferation and invasion in osteosarcoma through targeting miR-874-3p/SOX12 axis.
      Title: LncRNA CASC9 promotes cell proliferation and invasion in osteosarcoma through targeting miR-874-3p/SOX12 axis.
    4. LncRNA CASC9 activated by STAT3 promotes the invasion of breast cancer and the formation of lymphatic vessels by enhancing H3K27ac-activated SOX4.
      Title: LncRNA CASC9 activated by STAT3 promotes the invasion of breast cancer and the formation of lymphatic vessels by enhancing H3K27ac-activated SOX4.
    5. Abnormal expression of lncRNA CASC9 in pneumonia children with respiratory failure and its feasible value for the clinical diagnosis of patients.
      Title: Abnormal expression of lncRNA CASC9 in pneumonia children with respiratory failure and its feasible value for the clinical diagnosis of patients.
    6. Silencing LncRNA CASC9 inhibits proliferation and invasion of colorectal cancer cells by MiR-542-3p/ILK.
      Title: Silencing LncRNA CASC9 inhibits proliferation and invasion of colorectal cancer cells by MiR-542-3p/ILK.
    7. Long non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2.
      Title: Long non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2.
    8. CASC9 plays a role in salivary adenoid cystic carcinoma in vitro by upregulation of ACLY.
      Title: CASC9 plays a role in salivary adenoid cystic carcinoma in vitro by upregulation of ACLY.
    9. Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-kappaB axis promotes proliferation and migration in breast cancer.
      Title: Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer.
    10. LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling.
      Title: LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Whole genome association scan for genetic polymorphisms influencing information processing speed.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • ESCC-associated lncRNA
    • cancer susceptibility 9 (non-protein coding)
    • cancer susceptibility candidate 9 (non-protein coding)
    • esophageal squamous cell carcinoma associated lncRNA-1
    • esophageal squamous cell carcinoma sssociated lncRNA-1
    • long intergenic non-protein coding RNA 981

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_103848.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AI205540, BC062758, CN273839
      Related
      ENST00000504531.3

    2. NR_103849.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons and contains an alternate 5' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC022274

    3. NR_103850.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC022274
      Related
      ENST00000670695.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      75223117..75278889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      75652630..75708379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials