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    Brd7-9 Bromodomain containing 7/9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brd7-9provided by FlyBase
    Official Full Name
    Bromodomain containing 7/9provided by FlyBase
    Primary source
    FLYBASE:FBgn0031947
    Locus tag
    Dmel_CG7154
    See related
    AllianceGenome:FB:FBgn0031947
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Brd7; BRD7; BRD7/9; Brd9; CG7154; Dmel\CG7154
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of brahma complex. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Brd7-9 in Genome Data Viewer
    Location:
    28C3-28C3; 2-28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7782865..7786061)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7782865..7786061)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Urate oxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lysine ketoglutarate reductase/saccharopine dehydrogenase Neighboring gene long non-coding RNA:CR44825

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers. Hendy O, et al. Mol Cell, 2022 Oct 6. PMID 36113480, Free PMC Article
    2. Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes. Mashtalir N, et al. Cell, 2018 Nov 15. PMID 30343899, Free PMC Article
    3. Transcriptional cofactors display specificity for distinct types of core promoters. Haberle V, et al. Nature, 2019 Jun. PMID 31092928, Free PMC Article
    4. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Barish S, et al. Am J Hum Genet, 2020 Dec 3. PMID 33232675, Free PMC Article
    5. Transcriptional regulation by trithorax-group proteins. Kingston RE, et al. Cold Spring Harb Perspect Biol, 2014 Oct 1. PMID 25274705, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain containing 7/9
    Names
    Brd7-9-PA
    CG7154-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7782865..7786061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135304.3 → NP_609148.1  bromodomain containing 7/9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLX2
      Related
      FBpp0079111
      Conserved Domains (2) summary
      cd05513
      Location:279 → 376
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:440 → 687
      DUF3512; Domain of unknown function (DUF3512)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLX2 Q9VLX2

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