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    PLP1 Plp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PLP1
    Official Full Name
    Plp1p
    Primary source
    SGD:S000002591
    Locus tag
    YDR183W
    See related
    AllianceGenome:SGD:S000002591; FungiDB:YDR183W; VEuPathDB:YDR183W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables G-protein beta/gamma-subunit complex binding activity. Involved in cellular response to pheromone; positive regulation of transcription by RNA polymerase II; and protein folding. Predicted to be active in cytoplasm. Orthologous to human TXNDC9 (thioredoxin domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PLP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (829585..830277)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative lipid phosphatase CDC1 Neighboring gene uncharacterized protein Neighboring gene Atc1p Neighboring gene Ups3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Plp1 and Plp2, two homologues of phosducin in yeast. Flanary PL, et al. J Biol Chem, 2000 Jun 16. PMID 10749875
    2. A novel step in beta-tubulin folding is important for heterodimer formation in Saccharomyces cerevisiae. Lacefield S, et al. Genetics, 2003 Oct. PMID 14573467, Free PMC Article
    3. Consequences of defective tubulin folding on heterodimer levels, mitosis and spindle morphology in Saccharomyces cerevisiae. Lacefield S, et al. Genetics, 2006 Jun. PMID 16582437, Free PMC Article
    4. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. Stirling PC, et al. J Biol Chem, 2006 Mar 17. PMID 16415341
    5. Multiple pathways influence mitochondrial inheritance in budding yeast. Frederick RL, et al. Genetics, 2008 Feb. PMID 18245340, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Plp1p
    NP_010469.3
    • Protein that interacts with CCT (chaperonin containing TCP-1) complex; has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      829585..830277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180491.3 → NP_010469.3  TPA: Plp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010469.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSG7, Q04004
      UniProtKB/TrEMBL
      A6ZYE3, B3LG98, B5VG77, C7GN12, C8Z597, G2WAT3
      Conserved Domains (1) summary
      cd02989
      Location:80 → 192
      Phd_like_TxnDC9; Phosducin (Phd)-like family, Thioredoxin (TRX) domain containing protein 9 (TxnDC9) subfamily; composed of predominantly uncharacterized eukaryotic proteins, containing a TRX-like domain without the redox active CXXC motif. The gene name for the human ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04004.1

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