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    RAX1 Rax1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RAX1
    Official Full Name
    Rax1p
    Primary source
    SGD:S000005827
    Locus tag
    YOR301W
    See related
    AllianceGenome:SGD:S000005827; FungiDB:YOR301W; VEuPathDB:YOR301W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in axial cellular bud site selection; bipolar cellular bud site selection; and protein localization. Located in cellular bud neck and cellular bud scar. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RAX1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (880965..882272)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene multiprotein-bridging factor 1 Neighboring gene exomer complex subunit Neighboring gene uncharacterized protein Neighboring gene carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast. Chen T, et al. Science, 2000 Dec 8. PMID 11110666
    2. Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient sensing in Saccharomyces cerevisiae. Vasen G, et al. Proc Natl Acad Sci U S A, 2020 Mar 24. PMID 32152126, Free PMC Article
    3. Sequential logic of polarity determination during the haploid-to-diploid transition in Saccharomyces cerevisiae. Zapanta Rinonos S, et al. Eukaryot Cell, 2014 Nov. PMID 25172767, Free PMC Article
    4. Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast. Kang PJ, et al. Mol Biol Cell, 2004 Nov. PMID 15356260, Free PMC Article
    5. Distinct domains of yeast cortical tag proteins Bud8p and Bud9p confer polar localization and functionality. Krappmann AB, et al. Mol Biol Cell, 2007 Sep. PMID 17581861, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rax1p and Rax2p interact closely with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical landmarks for bipolar budding
      Title: Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rax1p
    NP_014945.3
    • Protein involved in establishing bud site selection; localizes to the bud neck and previous sites of cell division (bud scars or cytokinesis remnants (CRMs); localization to both sites is interdependent with Rax2p; required with Rax2p to anchor Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established, preventing repolarization of cells at previous division sites; predicted type IIIa transmembrane protein with similarity to members of the insulin-related peptide superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      880965..882272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183720.3 → NP_014945.3  TPA: Rax1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014945.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W300, Q08760
      UniProtKB/TrEMBL
      A6ZPD6, B3LJW5, C7GNW0, G2WNG7, N1NYW6
      Conserved Domains (1) summary
      smart00315
      Location:189 → 255
      RGS; Regulator of G protein signalling domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08760.1

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