MDJ2 Mdj2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MDJ2
Official Full Name: Mdj2p
Primary source: SGD:S000005272
Locus tag: YNL328C
See related: AllianceGenome:SGD:S000005272; FungiDB:YNL328C; VEuPathDB:YNL328C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATPase activator activity. Involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane. Part of PAM complex, Tim23 associated import motor. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 5. Orthologous to human DNAJC15 (DnaJ heat shock protein family (Hsp40) member C15) and DNAJC19 (DnaJ heat shock protein family (Hsp40) member C19). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

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Mdj2 is a functional J protein and a component of the mitochondrial import motor TIM23.
Title: The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein import into mitochondrial matrix	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IBA Inferred from Biological aspect of Ancestor more info
part_of PAM complex, Tim23 associated import motor	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014071.1

Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain

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The following sections contain reference sequences that belong to a specific genome build. Explain