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    olf413 olf413 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    olf413provided by FlyBase
    Official Full Name
    olf413provided by FlyBase
    Primary source
    FLYBASE:FBgn0037153
    Locus tag
    Dmel_CG12673
    See related
    AllianceGenome:FB:FBgn0037153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12673; CG14461; CG7495; CR33185; Dmel\CG12673; Olf413
    Summary
    Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; central brain primordium; dorsal ectoderm; and ganglia. Orthologous to human MOXD2P (monooxygenase DBH like 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See olf413 in Genome Data Viewer
    Location:
    79C2-79D2; 3-47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22136090..22247702)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22129190..22240802)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene male-specific opa containing gene Neighboring gene long non-coding RNA:CR45236 Neighboring gene long non-coding RNA:CR45971 Neighboring gene long non-coding RNA:CR45972 Neighboring gene long non-coding RNA:CR45035 Neighboring gene uncharacterized protein Neighboring gene RIC1 homolog Neighboring gene Dead-box-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. olf413, a putative octopamine biosynthesis pathway gene is required for negative geotactic motor function in Drosophila melanogaster. Ramya R, et al. J Genet, 2023. PMID 38073169
    2. olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster. Ramya R, et al. BMC Res Notes, 2024 Feb 7. PMID 38326892, Free PMC Article
    3. Identification of genetic modifiers of lifespan on a high sugar diet in the Drosophila Genetic Reference Panel. Patel SP, et al. Heliyon, 2021 Jun. PMID 34141921, Free PMC Article
    4. Signatures of Insecticide Selection in the Genome of Drosophila melanogaster. Duneau D, et al. G3 (Bethesda), 2018 Nov 6. PMID 30190420, Free PMC Article
    5. Context-dependent genetic architecture of Drosophila life span. Huang W, et al. PLoS Biol, 2020 Mar. PMID 32134916, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster.
      Title: olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster.
    2. olf413, a putative octopamine biosynthesis pathway gene is required for negative geotactic motor function in Drosophila melanogaster.
      Title: olf413, a putative octopamine biosynthesis pathway gene is required for negative geotactic motor function in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dopamine beta-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine beta-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dopamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in norepinephrine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in octopamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in secretory granule membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olf413
    Names
    CG12673-PB
    CG12673-PC
    olf413-PB
    olf413-PC
    NP_001262204.1
    NP_730711.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22136090..22247702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275275.1 → NP_001262204.1  olf413, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262204.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NP60, Q9GTU8, Q9VNV6
      UniProtKB/TrEMBL
      M9PDA4
      Conserved Domains (3) summary
      cd09631
      Location:111 → 243
      DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
      pfam01082
      Location:282 → 407
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:438 → 583
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    2. NM_168948.5 → NP_730711.3  olf413, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730711.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NP60, Q9GTU8, Q9VNV6
      UniProtKB/TrEMBL
      M9PDA4
      Conserved Domains (3) summary
      cd09631
      Location:111 → 243
      DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
      pfam01082
      Location:282 → 407
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:438 → 583
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDA4 M9PDA4
    Q6NP60.1 Q6NP60

    Gene LinkOut

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