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    Grasp65 Grasp65 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grasp65provided by FlyBase
    Official Full Name
    Grasp65provided by FlyBase
    Primary source
    FLYBASE:FBgn0036919
    Locus tag
    Dmel_CG7809
    See related
    AllianceGenome:FB:FBgn0036919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7809; dgrasp; dGrasp; dGRASP; dGrasp65; Dmel\CG7809; GRASP; GRASP65
    Summary
    Involved in several processes, including morphogenesis of follicular epithelium; positive regulation of lipid storage; and regulation of imaginal disc-derived wing size. Located in several cellular components, including Golgi stack; Golgi-associated vesicle; and apical cortex. Is expressed in adult heart; eye disc; larval central nervous system; larval ventral nerve cord; and photoreceptor neurons. Used to study obesity. Orthologous to several human genes including GORASP2 (golgi reassembly stacking protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Grasp65 in Genome Data Viewer
    Location:
    76D5-76D5; 3-46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19924943..19927175)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19918043..19920275)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Su(z)12 Neighboring gene Prefoldin 6 Neighboring gene uncharacterized protein Neighboring gene RhoGDI Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The multiple facets of the Golgi reassembly stacking proteins. Vinke FP, et al. Biochem J, 2011 Feb 1. PMID 21235525
    2. The study of muscle remodeling in Drosophila metamorphosis using in vivo microscopy and bioimage informatics. Chinta R, et al. BMC Bioinformatics, 2012. PMID 23282138, Free PMC Article
    3. The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium. Giuliani G, et al. Nucleic Acids Res, 2014 Feb. PMID 24217913, Free PMC Article
    4. Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners. Pirone L, et al. Biochimie, 2016 Dec. PMID 27678190
    5. Grasp55(-/-) mice display impaired fat absorption and resistance to high-fat diet-induced obesity. Kim J, et al. Nat Commun, 2020 Mar 17. PMID 32184397, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that insomniac protein (INC) recognize its potential partners Cul3 and dGRASP.
      Title: Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners.
    2. Identification of two putative HOW Response Elements within the dgrasp open reading frame for binding to Held Out Wings (HOW).
      Title: The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium.
    3. dGRASP-mediated noncanonical secretion route allows for developmental regulation of integrin function upon epithelial remodeling.
      Title: dGRASP-mediated noncanonical integrin secretion is required for Drosophila epithelial remodeling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of imaginal disc-derived wing size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in wing disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Grasp65
    Names
    CG7809-PA
    Grasp65-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19924943..19927175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140903.2 → NP_649160.1  Grasp65 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW57
      Related
      FBpp0074664
      Conserved Domains (2) summary
      pfam04495
      Location:69 → 205
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:14 → 100
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VW57 Q9VW57

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