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    Snx6 Sorting nexin 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx6provided by FlyBase
    Official Full Name
    Sorting nexin 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0032005
    Locus tag
    Dmel_CG8282
    See related
    AllianceGenome:FB:FBgn0032005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8282; Dmel\CG8282; DmSNX6; Dsnx6; snx6; SNX6
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in phagosome-lysosome fusion involved in apoptotic cell clearance and retrograde transport, endosome to Golgi. Predicted to be located in endosome. Predicted to be part of retromer, tubulation complex. Is expressed in adult head; adult heart; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to human SNX32 (sorting nexin 32); SNX5 (sorting nexin 5); and SNX6 (sorting nexin 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Snx6 in Genome Data Viewer
    Location:
    28F3-28F3; 2-30 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8218071..8220741, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8218071..8220741, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PDGF- and VEGF-receptor related Neighboring gene Serpin 28F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Simonetti B, et al. Nat Cell Biol, 2019 Oct. PMID 31576058, Free PMC Article
    2. Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. Koumandou VL, et al. J Cell Sci, 2011 May 1. PMID 21502137, Free PMC Article
    3. Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits. Evangelou A, et al. G3 (Bethesda), 2019 Nov 5. PMID 31540975, Free PMC Article
    4. Mistargeting of secretory cargo in retromer-deficient cells. Neuman SD, et al. Dis Model Mech, 2021 Jan 1. PMID 33380435, Free PMC Article
    5. Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions. Strutt H, et al. Curr Biol, 2019 Feb 4. PMID 30661800, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phagosome-lysosome fusion involved in apoptotic cell clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in positive regulation of Wnt protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of retromer, tubulation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin 6
    Names
    CG8282-PA
    CG8282-PB
    Snx6-PA
    Snx6-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8218071..8220741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135355.4 → NP_609199.1  sorting nexin 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T083, Q9VLQ9
      Related
      FBpp0079247
      Conserved Domains (2) summary
      cd06892
      Location:72 → 212
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cd07621
      Location:228 → 446
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6

    2. NM_001259010.2 → NP_001245939.1  sorting nexin 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDI3
      Conserved Domains (2) summary
      cd06892
      Location:72 → 212
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cd07621
      Location:228 → 452
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDI3 M9NDI3
    Q9VLQ9 Q9VLQ9

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