PGRP-SC1b Peptidoglycan recognition protein SC1b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PGRP-SC1bprovided by FlyBase
Official Full Name: Peptidoglycan recognition protein SC1bprovided by FlyBase
Primary source: FLYBASE:FBgn0033327
Locus tag: Dmel_CG8577
See related: AllianceGenome:FB:FBgn0033327
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8577; CT8705; Dmel\CG8577; PGRP SC; pgrp-sc; PGRP-SC; pgrp-sc1; PGRP-SC1; PGRP-SC1B; SC1B
Summary: Enables N-acetylmuramoyl-L-alanine amidase activity. Involved in Toll receptor ligand protein activation cascade; negative regulation of defense response to bacterium; and peptidoglycan catabolic process. Predicted to be located in extracellular region. Is expressed in embryonic/larval gut and embryonic/larval proventriculus. Orthologous to human PGLYRP1 (peptidoglycan recognition protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8713446..8715094)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4600951..4602599)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Toll receptor ligand protein activation cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidoglycan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptidoglycan catabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed

Names: CG8577-PA; CG8577-PB; PGRP-SC1b-PA; PGRP-SC1b-PB; Peptidoglycan-recognition protein-SC1b precursor

NP_001286209.1

NP_610409.1

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The following sections contain reference sequences that belong to a specific genome build. Explain