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    CG8708 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8708provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033271
    Locus tag
    Dmel_CG8708
    See related
    AllianceGenome:FB:FBgn0033271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.114; anon-WO0144478.10; dC1GalT2; Dmel\CG8708
    Summary
    Enables beta-1,3-galactosyltransferase activity. Involved in protein glycosylation. Located in Golgi medial cisterna. Is expressed in adult head; ejaculatory duct; gland; salivary gland body primordium; and testis. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8708 in Genome Data Viewer
    Location:
    44B5-44B7; 2-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8159406..8161565, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4046911..4049070, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44068 Neighboring gene transfer RNA:Isoleucine-AAT 1-2 Neighboring gene pseudo Neighboring gene Ras-related GTP binding C/D Neighboring gene uncharacterized protein Neighboring gene Rs1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the Drosophila core 1 beta1,3-galactosyltransferase gene that synthesizes T antigen in the embryonic central nervous system and hemocytes. Yoshida H, et al. Glycobiology, 2008 Dec. PMID 18824562
    2. Cloning and expression of human core 1 beta1,3-galactosyltransferase. Ju T, et al. J Biol Chem, 2002 Jan 4. PMID 11677243
    3. Characterization of mucin-type core-1 beta1-3 galactosyltransferase homologous enzymes in Drosophila melanogaster. Müller R, et al. FEBS J, 2005 Sep. PMID 16128800
    4. Cisterna-specific localization of glycosylation-related proteins to the Golgi apparatus. Yamamoto-Hino M, et al. Cell Struct Funct, 2012. PMID 22251795
    5. Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Lin YR, et al. Dev Dyn, 2008 Dec. PMID 18985719, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-1,3-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8708-PB
    CG8708-PC
    CG8708-PD
    NP_001246201.1
    NP_610360.2
    NP_724653.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8159406..8161565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259272.2 → NP_001246201.1  uncharacterized protein Dmel_CG8708, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K711, H1UUF8
      Conserved Domains (1) summary
      pfam10243
      Location:379 → 443
      MIP-T3; Microtubule-binding protein MIP-T3

    2. NM_136516.4 → NP_610360.2  uncharacterized protein Dmel_CG8708, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610360.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUF8, Q7JRF9
      Conserved Domains (1) summary
      pfam10243
      Location:385 → 449
      MIP-T3; Microtubule-binding protein MIP-T3

    3. NM_165594.3 → NP_724653.1  uncharacterized protein Dmel_CG8708, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUF8, Q7JRF9
      Related
      FBpp0087885
      Conserved Domains (1) summary
      pfam10243
      Location:385 → 449
      MIP-T3; Microtubule-binding protein MIP-T3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K711 A0A0B4K711
    Q7JRF9 Q7JRF9
    Q7K509 Q7K509

    Gene LinkOut

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