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    CG8777 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8777provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033376
    Locus tag
    Dmel_CG8777
    See related
    AllianceGenome:FB:FBgn0033376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8777; dSki3; ski3; SKI3
    Summary
    Involved in nuclear-transcribed mRNA catabolic process. Predicted to be part of Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human SKIC3 (SKI3 subunit of superkiller complex). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8777 in Genome Data Viewer
    Location:
    45A3-45A4; 2-60 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9098539..9103153)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4986044..4990658)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 4 Neighboring gene Cytosolic thiouridylase subunit 1 Neighboring gene Van Gogh Neighboring gene Phosphoglucomutase 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Degradation of hsp70 and other mRNAs in Drosophila via the 5' 3' pathway and its regulation by heat shock. Bönisch C, et al. J Biol Chem, 2007 Jul 27. PMID 17545151
    2. A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Molleston JM, et al. Genes Dev, 2016 Jul 15. PMID 27474443, Free PMC Article
    3. piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline. Lim AK, et al. J Cell Biol, 2009 Aug 10. PMID 19651888, Free PMC Article
    4. RNA degradation is required for the germ-cell to maternal transition in Drosophila. Blatt P, et al. Curr Biol, 2021 Jul 26. PMID 33989522, Free PMC Article
    5. Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Jiang N, et al. Mol Cell Biol, 2009 Jul. PMID 19380483, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ski complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ski complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8777-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9098539..9103153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136608.4 → NP_610452.2  uncharacterized protein Dmel_CG8777 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610452.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNB2
      Related
      FBpp0087646
      Conserved Domains (2) summary
      sd00006
      Location:511 → 539
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:407 → 472
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NNB2 Q6NNB2
    Q961V6 Q961V6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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