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    rho-7 rhomboid-7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rho-7provided by FlyBase
    Official Full Name
    rhomboid-7provided by FlyBase
    Primary source
    FLYBASE:FBgn0033672
    Locus tag
    Dmel_CG8972
    See related
    AllianceGenome:FB:FBgn0033672
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0138581.3; CG8972; Dmel\CG8972; PARL; R7; Rho-7; Rhomboid-7
    Summary
    Enables endopeptidase activity. Involved in mitochondrial fusion and protein processing. Located in mitochondrion. Is expressed in adult head; embryonic/larval midgut; larval muscle system; and organism. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rho-7 in Genome Data Viewer
    Location:
    48D5-48D5; 2-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11986513..11988787, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7874018..7876292, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene beta1,3-galactosyltransferase 1 Neighboring gene Ribonucleoside diphosphate reductase small subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45319 Neighboring gene long non-coding RNA:CR45318

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rhomboid-7 over-expression results in Opa1-like processing and malfunctioning mitochondria. Rahman M, et al. Biochem Biophys Res Commun, 2011 Oct 22. PMID 21945938
    2. Regulation of mitochondrial inner membrane fusion: divergent evolution with similar solutions? Wagener J. Curr Genet, 2016 May. PMID 26613727
    3. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Whitworth AJ, et al. Dis Model Mech, 2008 Sep-Oct. PMID 19048081, Free PMC Article
    4. Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. McQuibban GA, et al. Curr Biol, 2006 May 23. PMID 16713954
    5. PARL: The mitochondrial rhomboid protease. Spinazzi M, et al. Semin Cell Dev Biol, 2016 Dec. PMID 27502471

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhomboid-7
    Names
    CG8972-PA
    CG8972-PB
    Rhomboid-7
    rho-7-PA
    rho-7-PB
    NP_001286324.1
    NP_523704.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11986513..11988787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299395.1 → NP_001286324.1  rhomboid-7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8R8, Q8MQY3
      Conserved Domains (1) summary
      pfam01694
      Location:186 → 327
      Rhomboid; Rhomboid family

    2. NM_078980.4 → NP_523704.1  rhomboid-7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8R8, Q8MQY3
      Related
      FBpp0087151
      Conserved Domains (1) summary
      pfam01694
      Location:186 → 327
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8R8.1 A1Z8R8

    Gene LinkOut

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