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    CG45002 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG45002provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266354
    Locus tag
    Dmel_CG45002
    See related
    AllianceGenome:FB:FBgn0266354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH06235; CG34326; CG9059; Dmel\CG45002
    Old locus tag
    Dmel_CG34326; Dmel_CG9059
    Summary
    Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG45002 in Genome Data Viewer
    Location:
    15D1-15E1; 1-56 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16969069..17066732, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16863102..16960765, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 15B Neighboring gene uncharacterized protein Neighboring gene Ubr1 ubiquitin ligase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene wacky

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster. Chihara CJ, et al. J Insect Sci, 2005 Nov 2. PMID 17119608, Free PMC Article
    2. Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster. Nicol A, et al. PLoS One, 2024. PMID 39196987, Free PMC Article
    3. Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. Miller DE, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26903656, Free PMC Article
    4. The genetic architecture of larval aggregation behavior in Drosophila. McKinney RM, et al. J Neurogenet, 2021 Sep. PMID 33629904
    5. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c17058174-17057989 mobile_element_type = transposon:pogo{}146

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG45002-PD
    CG45002-PE
    CG45002-PF
    CG45002-PG
    CG45002-PH
    CG45002-PI
    CG45002-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16969069..17066732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298429.1 → NP_001285358.1  uncharacterized protein Dmel_CG45002, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM8, X2JFI2
      Conserved Domains (3) summary
      COG1506
      Location:653 → 957
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:267 → 670
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:754 → 958
      Abhydrolase; alpha/beta hydrolases

    2. NM_001298428.1 → NP_001285357.1  uncharacterized protein Dmel_CG45002, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM8, X2JKT7
      Conserved Domains (3) summary
      COG1506
      Location:661 → 965
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:275 → 678
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:762 → 966
      Abhydrolase; alpha/beta hydrolases

    3. NM_001272703.1 → NP_001259632.1  uncharacterized protein Dmel_CG45002, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM8, M9PHX1
      Conserved Domains (3) summary
      COG1506
      Location:648 → 952
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:262 → 665
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:749 → 953
      Abhydrolase; alpha/beta hydrolases

    4. NM_132957.3 → NP_573185.3  uncharacterized protein Dmel_CG45002, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573185.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM8, Q9VX90
      Conserved Domains (3) summary
      COG1506
      Location:648 → 952
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:262 → 665
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:749 → 953
      Abhydrolase; alpha/beta hydrolases

    5. NM_001144740.2 → NP_001138212.1  uncharacterized protein Dmel_CG45002, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM8, B7Z0Z7
      Conserved Domains (3) summary
      COG1506
      Location:664 → 968
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:278 → 681
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:765 → 969
      Abhydrolase; alpha/beta hydrolases

    6. NM_167553.2 → NP_728041.3  uncharacterized protein Dmel_CG45002, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728041.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM8, Q8IR04
      Conserved Domains (3) summary
      COG1506
      Location:664 → 968
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:278 → 681
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:765 → 969
      Abhydrolase; alpha/beta hydrolases

    7. NM_001272704.1 → NP_001259633.1  uncharacterized protein Dmel_CG45002, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM8, B7Z0Z7
      Conserved Domains (3) summary
      COG1506
      Location:664 → 968
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:278 → 681
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:765 → 969
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0Z7 B7Z0Z7
    M9PHX1 M9PHX1
    Q8IR04 Q8IR04
    Q9VX90 Q9VX90
    X2JFI2 X2JFI2
    X2JKT7 X2JKT7

    Gene LinkOut

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