Slc34a3 solute carrier family 34 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc34a3provided by RGD
Official Full Name: solute carrier family 34 member 3provided by RGD
Primary source: RGD:708551
See related: EnsemblRapid:ENSRNOG00000010451 AllianceGenome:RGD:708551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sodium:phosphate symporter activity. Involved in response to magnesium ion; response to nutrient levels; and sodium-dependent phosphate transport. Located in apical plasma membrane and brush border membrane. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 259.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28442455..28447997, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8044294..8050034, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2448391..2454019, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Magnesium deficiency induces downregulation of 1alpha(OH)ase and type IIa and IIc Na/Pi cotransporters, and upregulation of 24(OH)ase in the kidney.
Title: Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats.
expression in renal brush border not reduced by parathyroid hormones
Title: Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.
Results describe the regulation of the sodium/phosphate cotransporters SCL34A3 and SLC20A2 during phosphate deprivation and acidosis in rat kidney.
Title: Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
Title: Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
Under a high-Mg2+ diet, NaPi-IIa expression is dependent on PTH levels, whereas NaPi-IIc expression seems to be independent of PTH levels
Title: Magnesium stimulates renal phosphate reabsorption.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables sodium:phosphate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:phosphate symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular phosphate ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular phosphate ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium-dependent phosphate transport protein 2C

Names: Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; Na+/Pi-cotransporter type IIc; naPi-2c; sodium-phosphate transport protein 2C; sodium/phosphate cotransporter 2C; solute carrier family 34 (sodium phosphate), member 3; solute carrier family 34 (type II sodium/phosphate contransporter), member 3; solute carrier family 34 (type II sodium/phosphate cotransporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139338.3 → NP_647554.2 sodium-dependent phosphate transport protein 2C

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8K4R8

UniProtKB/TrEMBL

A6JT20, G3V7E1

Related

ENSRNOP00000014060.3, ENSRNOT00000014060.8

Conserved Domains (1) summary

TIGR01013
Location:79 → 565

2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28442455..28447997 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104250.2 → XP_038960178.1 sodium-dependent phosphate transport protein 2C isoform X2

UniProtKB/Swiss-Prot

Q8K4R8

UniProtKB/TrEMBL

A6JT20, G3V7E1

Conserved Domains (1) summary

TIGR01013
Location:79 → 565

2a58; Phosphate:Na+ Symporter (PNaS) Family
XM_063283081.1 → XP_063139151.1 sodium-dependent phosphate transport protein 2C isoform X1

UniProtKB/Swiss-Prot

Q8K4R8

UniProtKB/TrEMBL

A0A0G2K7V6