Dgcr2 DiGeorge syndrome critical region gene 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dgcr2provided by RGD
Full Name: DiGeorge syndrome critical region gene 2provided by RGD
Primary source: RGD:1310567
See related: EnsemblRapid:ENSRNOG00000061814 AllianceGenome:RGD:1310567
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in cognition. Predicted to act upstream of or within response to xenobiotic stimulus. Predicted to be located in membrane. Orthologous to human DGCR2 (DiGeorge syndrome critical region gene 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: GeneIDs: 360742 and 103693608 are annotated independently on Rnor_6.0 but may be redundant loci. [12 Feb 2015]
Expression: Biased expression in Thymus (RPKM 197.9), Kidney (RPKM 192.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96598247..96648791)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83093961..83144507)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87242441..87290806)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AW554570 (e-PCR)
- UniSTS:209177

A001T42 (e-PCR)
- UniSTS:7873

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integral membrane protein DGCR2/IDD

Names: integral membrane protein DGCR2/IDD-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012146.1 → NP_001012146.1 integral membrane protein DGCR2/IDD precursor

See identical proteins and their annotated locations for NP_001012146.1

Status: PROVISIONAL

Source sequence(s)

BC081905

UniProtKB/TrEMBL

A0A0G2JUR3, A0A8I5ZQN6, A6JSJ9, E9PTM9, Q66HD9

Conserved Domains (3) summary

cd03599
Location:111 → 263

CLECT_DGCR2_like; C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)

smart00214
Location:267 → 325

VWC; von Willebrand factor (vWF) type C domain

cd00112
Location:30 → 66

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

96598247..96648791

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088526.2 → XP_038944454.1 integral membrane protein DGCR2/IDD isoform X1

UniProtKB/TrEMBL

A0A8I5ZQN6

Related

ENSRNOP00000069196.2, ENSRNOT00000083415.3

Conserved Domains (3) summary

cd03599
Location:114 → 266

CLECT_DGCR2_like; C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)

smart00214
Location:270 → 328

VWC; von Willebrand factor (vWF) type C domain

cd00112
Location:30 → 66

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039088528.2 → XP_038944456.1 integral membrane protein DGCR2/IDD isoform X2

Conserved Domains (3) summary

cd03599
Location:114 → 266

CLECT_DGCR2_like; C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)

smart00214
Location:270 → 328

VWC; von Willebrand factor (vWF) type C domain

cd00112
Location:30 → 66

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_063270658.1 → XP_063126728.1 integral membrane protein DGCR2/IDD isoform X3