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    Trnt1 tRNA nucleotidyl transferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trnt1provided by RGD
    Official Full Name
    tRNA nucleotidyl transferase 1provided by RGD
    Primary source
    RGD:1308857
    See related
    EnsemblRapid:ENSRNOG00000006432 AllianceGenome:RGD:1308857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable CCACCA tRNA nucleotidyltransferase activity; protein homodimerization activity; and tRNA binding activity. Predicted to be involved in rescue of stalled ribosome and tRNA metabolic process. Predicted to be active in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 200.8), Thymus (RPKM 195.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trnt1 in Genome Data Viewer
    Location:
    4q41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (141236937..141259700)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (139681115..139703611)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (138855497..138869217)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene contactin 4 Neighboring gene uncharacterized LOC120102502 Neighboring gene U6 spliceosomal RNA Neighboring gene interleukin 5 receptor subunit alpha Neighboring gene cereblon Neighboring gene uncharacterized LOC134486621 Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). Chakraborty PK, et al. Blood, 2014 Oct 30. PMID 25193871, Free PMC Article
    2. Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. Nagaike T, et al. J Biol Chem, 2001 Oct 26. PMID 11504732
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124985

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCA tRNA nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CCACCA tRNA nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CCA tRNA nucleotidyltransferase 1, mitochondrial
    Names
    tRNA nucleotidyl transferase, CCA-adding, 1
    tRNA-nucleotidyltransferase 1, mitochondrial
    NP_001019432.1
    XP_008761414.1
    XP_008761415.1
    XP_038963555.1
    XP_063142154.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024261.3 → NP_001019432.1  CCA tRNA nucleotidyltransferase 1, mitochondrial

      See identical proteins and their annotated locations for NP_001019432.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      F7EZK1, Q4VBH2
      Conserved Domains (1) summary
      COG0617
      Location:40 → 417
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      141236937..141259700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286084.1 → XP_063142154.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPS5

    2. XM_039107627.2 → XP_038963555.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      F7EZK1, Q4VBH2
      Related
      ENSRNOP00000080320.2, ENSRNOT00000119654.2
      Conserved Domains (1) summary
      COG0617
      Location:40 → 417
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

    3. XM_008763192.4 → XP_008761414.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_008761414.1

      UniProtKB/TrEMBL
      F7EZK1, Q4VBH2
      Conserved Domains (1) summary
      COG0617
      Location:40 → 417
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

    4. XM_008763193.4 → XP_008761415.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_008761415.1

      UniProtKB/TrEMBL
      F7EZK1, Q4VBH2
      Conserved Domains (1) summary
      COG0617
      Location:40 → 417
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version

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