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    mAcon1 Mitochondrial aconitase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mAcon1provided by FlyBase
    Official Full Name
    Mitochondrial aconitase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010100
    Locus tag
    Dmel_CG9244
    See related
    AllianceGenome:FB:FBgn0010100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    acon; Acon; ACON-1; aconitase; AconM; BEST:GH10550; CG9244; Dmel\CG9244; hsp60; i204; i59; l(2)07054; m-acon; m-Acon; M-Acon; mAc; mAcon; mACON
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Involved in tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Used to study Parkinson's disease and infantile cerebellar-retinal degeneration. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mAcon1 in Genome Data Viewer
    Location:
    39A7-39A7; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21168570..21173185)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21168570..21173185)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene burgundy

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Das N, et al. Biochem J, 2001 Nov 15. PMID 11696009, Free PMC Article
    2. Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency. Cheng Z, et al. Biochem Biophys Res Commun, 2013 Mar 29. PMID 23438437
    3. Mitochondrial aconitase 1 regulates age-related memory impairment via autophagy/mitophagy-mediated neural plasticity in middle-aged flies. Cho YH, et al. Aging Cell, 2021 Dec. PMID 34799973, Free PMC Article
    4. Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production. Wu Z, et al. Neurobiol Aging, 2012 Jan. PMID 20674094
    5. Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging. Paul A, et al. Mech Ageing Dev, 2007 Nov-Dec. PMID 18078670, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aconitate hydratase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial aconitase 1
    Names
    ACONITASE
    CG9244-PB
    CG9244-PD
    CG9244-PE
    CG9244-PF
    m-aconitase
    mAcon1-PB
    mAcon1-PD
    mAcon1-PE
    mAcon1-PF
    mitochondrial aconitase
    NP_001097186.2
    NP_001163030.1
    NP_001286119.1
    NP_524708.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21168570..21173185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299190.1 → NP_001286119.1  mitochondrial aconitase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFX1, Q9VIE8
      Conserved Domains (3) summary
      cd01584
      Location:102 → 513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595 → 743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52 → 782
      aconitase_mito; aconitate hydratase, mitochondrial

    2. NM_001103716.2 → NP_001097186.2  mitochondrial aconitase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFX1, Q9VIE8
      Conserved Domains (3) summary
      cd01584
      Location:102 → 513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595 → 743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52 → 782
      aconitase_mito; aconitate hydratase, mitochondrial

    3. NM_001169559.2 → NP_001163030.1  mitochondrial aconitase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFX1, Q9VIE8
      Conserved Domains (3) summary
      cd01584
      Location:102 → 513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595 → 743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52 → 782
      aconitase_mito; aconitate hydratase, mitochondrial

    4. NM_079969.5 → NP_524708.1  mitochondrial aconitase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFX1, Q9VIE8
      Related
      FBpp0081002
      Conserved Domains (3) summary
      cd01584
      Location:102 → 513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595 → 743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52 → 782
      aconitase_mito; aconitate hydratase, mitochondrial
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NFX0 Q9NFX0
    Q9VIE8 Q9VIE8

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