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    Rapgefl1 Rap guanine nucleotide exchange factor like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rapgefl1provided by RGD
    Official Full Name
    Rap guanine nucleotide exchange factor like 1provided by RGD
    Primary source
    RGD:1563269
    See related
    EnsemblRapid:ENSRNOG00000027871 AllianceGenome:RGD:1563269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase-mediated signal transduction. Orthologous to human RAPGEFL1 (Rap guanine nucleotide exchange factor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 85.4), Kidney (RPKM 12.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rapgefl1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84289980..84306614)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83793711..83810373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86749220..86765677)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 1 Neighboring gene CASC3 exon junction complex subunit Neighboring gene U6 spliceosomal RNA Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene cell division cycle 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109414

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor-like 1
    Names
    Rap guanine nucleotide exchange factor (GEF)-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427833.1 → NP_001414762.1  rap guanine nucleotide exchange factor-like 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8J8XFA0
      Related
      ENSRNOP00000036373.6, ENSRNOT00000030425.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84289980..84306614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087397.2 → XP_038943325.1  rap guanine nucleotide exchange factor-like 1 isoform X1

      Conserved Domains (1) summary
      smart00147
      Location:245 → 483
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
    Molecular Biology Databases
    Research Materials