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    Abhd17b abhydrolase domain containing 17B, depalmitoylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309399, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Abhd17bprovided by RGD
    Official Full Name
    abhydrolase domain containing 17B, depalmitoylaseprovided by RGD
    Primary source
    RGD:1305246
    See related
    EnsemblRapid:ENSRNOG00000012514 AllianceGenome:RGD:1305246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cgi67l; Fam108b1; RGD1305246
    Summary
    Predicted to enable palmitoyl-(protein) hydrolase activity. Involved in regulation of postsynapse organization. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic recycling endosome membrane. Orthologous to human ABHD17B (abhydrolase domain containing 17B, depalmitoylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 183.6), Brain (RPKM 176.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abhd17b in Genome Data Viewer
    Location:
    1q51
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (228624821..228659254)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (219198294..219232733)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (239266140..239301133)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene similar to human chromosome 9 open reading frame 85 Neighboring gene uncharacterized LOC108348948 Neighboring gene small ribosomal subunit protein uS17-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. Lin DT, et al. Elife, 2015 Dec 23. PMID 26701913, Free PMC Article
    2. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, et al. Neuron, 2017 May 17. PMID 28521134
    3. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, et al. J Neurosci, 2016 Jun 15. PMID 27307232, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic recycling endosome membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha/beta hydrolase domain-containing protein 17B
    Names
    abhydrolase domain-containing protein 17B
    abhydrolase domain-containing protein FAM108B1
    family with sequence similarity 108, member B1
    protein ABHD17B
    NP_001014050.1
    XP_006231224.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014028.1 → NP_001014050.1  alpha/beta hydrolase domain-containing protein 17B

      Status: PROVISIONAL

      Source sequence(s)
      BC079229
      UniProtKB/Swiss-Prot
      Q6AY17
      UniProtKB/TrEMBL
      A0A8I5ZUP2, A6I0M6
      Conserved Domains (1) summary
      COG1073
      Location:93 → 285
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      228624821..228659254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231162.5 → XP_006231224.1  alpha/beta hydrolase domain-containing protein 17B isoform X1

      UniProtKB/Swiss-Prot
      Q6AY17
      UniProtKB/TrEMBL
      A0A8I5ZUP2, A6I0M6
      Related
      ENSRNOP00000047508.2, ENSRNOT00000044486.5
      Conserved Domains (1) summary
      COG1073
      Location:93 → 285
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY17.1 GenPept UniProtKB/Swiss-Prot:Q6AY17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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