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    Nudcd3 NudC domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100125378, updated on 9-Dec-2024

    Summary

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    Symbol
    Nudcd3provided by RGD
    Full Name
    NudC domain containing 3provided by RGD
    Primary source
    RGD:1642416
    See related
    EnsemblRapid:ENSRNOG00000056148 AllianceGenome:RGD:1642416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cilium assembly and protein localization to pericentriolar material. Predicted to be part of cytoplasmic dynein complex. Orthologous to human NUDCD3 (NudC domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 96.4), Thymus (RPKM 94.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nudcd3 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85190276..85273655, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80976330..81059183, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86326413..86333397, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906770.1 (39982..50084, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352789 Neighboring gene YKT6 v-SNARE homolog Neighboring gene calcium/calmodulin-dependent protein kinase II beta Neighboring gene uncharacterized LOC134481870 Neighboring gene NPC1 like intracellular cholesterol transporter 1 Neighboring gene ribosomal protein L13A, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport. Shao CY, et al. Traffic, 2013 Jul. PMID 23551859
    2. Subunit composition of the human cytoplasmic dynein-2 complex. Asante D, et al. J Cell Sci, 2014 Nov 1. PMID 25205765, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. knocking down both Ndel1 and NudCL almost blocked retrograde mitochondrial axonal transport.
      Title: Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125083

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nudC domain-containing protein 3
    Names
    nudC domain-containing protein 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103362.2 → NP_001096832.1  nudC domain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001096832.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K226, A0A8I6AIG0, Q32PY7
      Related
      ENSRNOP00000072079.2, ENSRNOT00000083191.3
      Conserved Domains (2) summary
      pfam14050
      Location:9 → 67
      Nudc_N; N-terminal conserved domain of Nudc
      cl00175
      Location:186 → 265
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    2. NM_001419338.1 → NP_001406267.1  nudC domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5Y9V8, A0A8I6A4I4, A6IKS1
      Related
      ENSRNOP00000087625.2, ENSRNOT00000112627.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      85190276..85273655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005492870.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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